{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:11:03Z","timestamp":1782177063037,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Children with severe atopic dermatitis (AD), refractory to conventional systemic treatment as well as single\u2010agent biologic and Janus kinase inhibitor (JAKi) such as abrocitinib, currently face a lack of treatment options. In response to this clinical conundrum, we present three cases of severe and refractory pediatric AD successfully managed with combined dupilumab and abrocitinib. These children had exhausted all conventional treatments and had undergone treatment with both dupilumab and abrocitinib individually, as well as dupilumab in conjunction with methotrexate. It was only when the combination of dupilumab and abrocitinib was introduced that they finally achieved noticeable and sustained improvements in disease control.<\/jats:p>","DOI":"10.1111\/pde.15761","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T01:05:47Z","timestamp":1728003947000},"page":"358-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Case Series of Refractory Pediatric Atopic Dermatitis Effectively Treated With Dupilumab in Combination With\u00a0Abrocitinib"],"prefix":"10.1111","volume":"42","author":[{"given":"Wei Chern Gavin","family":"Fong","sequence":"first","affiliation":[{"name":"Centre of Evidence Based Dermatology School of Medicine, University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Htet Hla Win","family":"Kaung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dermatology St John's Institute of Dermatology, King's College London and Guy's &amp; 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