{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:56:08Z","timestamp":1789145768026,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report the case of a 3\u2010year\u2010old boy who was diagnosed with childhood pemphigus vulgaris having developed oral lesions, gastrointestinal symptoms with esophageal involvement, and failure to thrive. He had a markedly increased total serum IgE level and peripheral blood eosinophilia. The pemphigus was recalcitrant to conventional therapies and, based on the coexisting characteristics of Th2 immune deviation, he was treated with dupilumab and has had sustained clinical improvement since starting treatment. The case illustrates the importance of recognizing pemphigus vulgaris in childhood, considerations for dupilumab therapy, and a potential pathophysiological links between pemphigus autoantibodies in early life, Th2 inflammation, and atopic disorder.<\/jats:p>","DOI":"10.1111\/pde.15779","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T09:01:02Z","timestamp":1733907662000},"page":"371-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pemphigus Vulgaris With Esophageal Involvement in an Atopic Child Successfully Treated With Dupilumab"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0480-3568","authenticated-orcid":false,"given":"Sonora","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Psychiatry Mount SInai Morningside\/West  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair A.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-9446","authenticated-orcid":false,"given":"Margaret E.","family":"Scollan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Vagelos College of Physicians and Surgeons and NewYork\u2010Presbyterian New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Defelice","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Vagelos College of Physicians and Surgeons and NewYork\u2010Presbyterian New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Leiferman","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Milner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Vagelos College of Physicians and Surgeons and NewYork\u2010Presbyterian New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-4831","authenticated-orcid":false,"given":"Christine T.","family":"Lauren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Vagelos College of Physicians and Surgeons and NewYork\u2010Presbyterian New York  New York New York USA"},{"name":"Department of Pediatrics Columbia University Vagelos College of Physicians and Surgeons and NewYork\u2010Presbyterian New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11226858"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.2012.01730.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825796"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.089"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5070\/D32511046147"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2526"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.10.035"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.611549"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205982"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/00099228221140801"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010022\u201000531\u20100"},{"key":"e_1_2_6_13_1","unstructured":"National Library of Medicine (U.S.) \u201cA Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid \u201d2020 https:\/\/beta.clinicaltrials.gov\/study\/NCT04206553?locStr=USA&country=United%20States&term=dupilumab&limit=100&cond=bullous&rank=1."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.05.040"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.11.025"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.05.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2739"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14924"}],"container-title":["Pediatric 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