{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:07:49Z","timestamp":1791389269395,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperimmunoglobulin E syndrome (HIES) is a group of rare genetic disorders characterized by severe atopic dermatitis and recurrent skin and pulmonary infections. The efficacy of dupilumab in pediatric patients with HIES\u2010associated severe atopic dermatitis is relatively understudied. Here, we present a series of three children with HIES, two with AD\u2010HIES caused by\n                    <jats:italic>STAT3<\/jats:italic>\n                    mutations, and one with AR\u2010HIES caused by biallelic mutations in\n                    <jats:italic>ZNF341<\/jats:italic>\n                    . In all cases, dupilumab treatment led to sustained clearance of severe atopic dermatitis over multiple years, as well as improvements in systemic symptoms of HIES.\n                  <\/jats:p>","DOI":"10.1111\/pde.15780","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T03:34:48Z","timestamp":1729222488000},"page":"376-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Improvement in Atopic Dermatitis and Recurrent Infection With Dupilumab in Children With Distinct Genetic Types\u00a0of Hyper\u2010\n                    <scp>IgE<\/scp>\n                    Syndrome: A Case Series and\u00a0Literature\u00a0Review"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-7536","authenticated-orcid":false,"given":"Jenna K.","family":"Dick","sequence":"first","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Boull","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara C.","family":"Pozos","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Children's Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-8285","authenticated-orcid":false,"given":"Sheilagh M.","family":"Maguiness","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology, Department of Dermatology University of Minnesota  Minneapolis Minnesota 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