{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:59:34Z","timestamp":1790816374467,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Binimetinib and selumetinib are two mitogen\u2010activated protein kinase kinase (MEK) inhibitors used to treat low\u2010grade gliomas and plexiform neurofibromas. Cutaneous toxicities are commonly associated with MEK inhibitors; however, limited studies have examined cutaneous effects in a pediatric population or whether toxicities vary between MEK inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an IRB\u2010approved, single\u2010center, retrospective review of pediatric neuro\u2010oncology patients on binimetinib or selumetinib who presented to NYU from April 2016 through July 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six children met inclusion criteria (23 females, 23 males) with a mean age of 11.7\u2009years. Thirty\u2010three were treated with binimetinib and 13 with selumetinib. Dermatologic adverse events were encountered in 97.8% of the cohort, and the most common were acneiform eruption (63.0%), paronychia (58.7%), and xerosis (54.3%). Children 12\u2009years and older were more likely to have acneiform eruption (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and seborrheic dermatitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while children under 12 were more likely to have xerosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). The incidence of cutaneous adverse events was significantly different between MEK inhibitors for folliculitis and hair pigment dilution (39.4% binimetinib, 0% selumetinib, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Significantly, more patients required MEK inhibitor dose reduction\/hold on binimetinib (87.9%) than selumetinib (46.2%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). Severity of cutaneous disease was not associated with tumor response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirms dermatologic adverse events are common in children on MEK inhibitors. Age appears to be associated with increased likelihood of certain cutaneous reactions. Overall, the selumetinib patients in our cohort presented with less severe adverse events and decreased risk of MEK inhibitor dose reduction\/hold. Our results will aid clinicians in providing appropriate counseling, treatments, and improved preventive care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15792","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:39:21Z","timestamp":1731044361000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cutaneous Toxicities of <scp>MEK<\/scp> Inhibitor Use in Children: A\u00a0Comparison of Binimetinib and Selumetinib"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9768-3831","authenticated-orcid":false,"given":"Carli D.","family":"Needle","sequence":"first","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yin","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor K.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soutrik","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devorah","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleb H.","family":"Yohay","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita R.","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikash S.","family":"Oza","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"469","article-title":"Regulation of Cell Cycle Progression and Apoptosis by the Ras\/Raf\/MEK\/ERK Pathway","volume":"22","author":"Chang F.","year":"2003","journal-title":"International Journal of Oncology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210422"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010141"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010010\u20109567\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.07.044"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27682"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14354"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128678"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14079"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T14:30:04Z","timestamp":1749133804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pde.15792"],"URL":"https:\/\/doi.org\/10.1111\/pde.15792","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"2024-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}