{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:06:44Z","timestamp":1765534004650,"version":"3.48.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Down syndrome (DS) is a common chromosomal disorder with distinct phenotypes and skin markers. This study reports\u00a039\u00a0DS\u00a0patients, aged 1\u201344 \u2009months, who presented from birth with rough, brownish skin in the dimples of their\u00a0knees\u00a0and\/or elbows.\u00a0Dermoscopy revealed hyperkeratosis with brownish scales, and biopsies in six cases showed\u00a0papillomatosis and\u00a0mild\u00a0hyperkeratosis. In the cases followed, the condition resolved spontaneously. Hyperkeratosis\u00a0in\u00a0the\u00a0skin\u00a0dimples\u00a0on\u00a0the knees and elbows seems to be a congenital and perhaps characteristic finding in patients with\u00a0DS.<\/jats:p>","DOI":"10.1111\/pde.15813","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T17:38:20Z","timestamp":1730914700000},"page":"322-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperkeratosis in Skin Dimples in Children With Down Syndrome"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-3208","authenticated-orcid":false,"given":"Susana","family":"Giraldi","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Division, Department of Pediatrics Federal University of Paran\u00e1, UFPR  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9671-5603","authenticated-orcid":false,"given":"Betina","family":"Werner","sequence":"additional","affiliation":[{"name":"Pathology Department Federal University of Paran\u00e1, UFPR  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-3540","authenticated-orcid":false,"given":"Mariana Aparecida","family":"Pasa Morgan","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Child and Adolescent Health Federal University of Paran\u00e1, UFPR  Curitiba Brazil"},{"name":"Ceres Faculty Medical School of S\u00e3o Jos\u00e9 Do Rio Preto  S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"627","volume-title":"Handbook of Genetic Skin Disorders","author":"Novice F. 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