{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:07:12Z","timestamp":1782727632523,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>A wholesale recommendation against use of live virus vaccines in patients treated with any medication classified as an immunosuppressant has been based on global theoretical concerns rather than clinical outcomes for specific drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective search of electronic medical records identified patients seen by the Allergy and\/or Dermatology services between 2017 and 2023 at a pediatric tertiary center who received a live attenuated vaccine during the 6\u2009week interval prior to the first prescription for methotrexate or dupilumab until 6\u2009weeks after the last prescription for either medication. Individual charts of identified patients were manually reviewed for evidence of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search identified 313 pediatric patients treated with dupilumab and\/or methotrexate during the 7\u2010year interval. Five of these patients received the combination measles, mumps, rubella, and varicella (MMRV) vaccine while on dupilumab and 4 while on methotrexate. Manual chart review was without evidence of adverse events for up to 6\u2009months after immunization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective search identified a small number of pediatric patients immunized with the live attenuated MMRV vaccine during concomitant treatment with dupilumab or methotrexate. No associated adverse events were identified. Further investigation is needed to establish the safety and efficacy of live vaccines in patients treated with these immunomodulating agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.15818","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T08:49:47Z","timestamp":1733906987000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Live Attenuated Vaccine Administration in Children Treated With Methotrexate or Dupilumab"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7065-8348","authenticated-orcid":false,"given":"Julia R.","family":"Hughes","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-6850","authenticated-orcid":false,"given":"Sino","family":"Mehrmal","sequence":"additional","affiliation":[{"name":"Department of Dermatology SSM Health and Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-0845","authenticated-orcid":false,"given":"Sana","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology SSM Health and Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SSM Health Cardinal Glennon Children's Hospital  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-9905","authenticated-orcid":false,"given":"Elaine C.","family":"Siegfried","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Dermatology SSM Health and Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13491"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010020\u201000413\u20108"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPED.2022.910026\/FULL"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.12.17981"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.01.037"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken436"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010021\u201000607\u20106"},{"key":"e_1_2_12_9_1","unstructured":"Advisory Committee on Immunization Practices \u201cVaccine Recommendations and Guidelines of the ACIP: Altered Immunocompetence \u201d2023 https:\/\/www.cdc.gov\/vaccines\/hcp\/acip\u2010recs\/general\u2010recs\/immunocompetence.html."},{"key":"e_1_2_12_10_1","unstructured":"\u201cDUPIXENT (dupilumab). Summary of product characteristics \u201d2013 https:\/\/doi.org\/10.18356\/c9646f63\u2010en\u2010fr."},{"key":"e_1_2_12_11_1","unstructured":"\u201cDUPIXENT (dupilumab). Highlights of prescribing information \u201d2024 https:\/\/www.regeneron.com\/downloads\/."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1298443"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","unstructured":"Red Book \u201cReport of the Committee on Infectious Diseases. 33rd ed. American Academy of Pediatrics; 2024 \u201d2024 https:\/\/doi.org\/10.1542\/9781610027373\u2010S1_004_006.","DOI":"10.1542\/9781610027373"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.011"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2021.12.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ANNRHEUMDIS\u20102021\u2010220597"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRIM.2023.101858"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ANNRHEUMDIS\u20102018\u2010213222"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541\u2010024\u201000805\u20103"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15518"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15327"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010020\u201000905\u20108"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:02:40Z","timestamp":1765533760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/pde.15818"],"URL":"https:\/\/doi.org\/10.1111\/pde.15818","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}