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A granulomatous variant of centrifugal miliaria profunda classic findings of granulomatous infiltrate on histology and centrifugal expansion of deep nodules or plaques. We report a rare case of the granulomatous variant of centrifugal miliaria in an 8\u2010month\u2010old boy, with associated cardiofaciocutaneous syndrome (CFCS) due to a pathogenic <jats:italic>MAP2K1<\/jats:italic> germline variant.<\/jats:p>","DOI":"10.1111\/pde.15827","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:59:51Z","timestamp":1737593991000},"page":"599-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Granulomatous Variant of Giant Centrifugal Miliaria Profunda in an 8\u2010Month\u2010Old Boy: Expanding the Dermatologic Phenotype of Cardiofaciocutaneous Syndrome"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1564-6056","authenticated-orcid":false,"given":"Hannah C.","family":"Tolson","sequence":"first","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-9879","authenticated-orcid":false,"given":"Fatmah","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Division of Dermatology Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Summit Health  Montville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lorsbach","sequence":"additional","affiliation":[{"name":"Division of Pathology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Grebe","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"},{"name":"Division of Genetics &amp; Metabolism Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supraja","family":"Prakash","sequence":"additional","affiliation":[{"name":"Division of Genetics &amp; Metabolism Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Picarsic","sequence":"additional","affiliation":[{"name":"Division of Pathology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"},{"name":"Division of Dermatology Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harper","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"},{"name":"Division of Dermatology Phoenix Children's  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_422_18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.2011.01666.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.1990.tb00671.x"},{"key":"e_1_2_8_5_1","volume-title":"StatPearls","author":"Guerra K. 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