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RTS has a broad phenotypic spectrum including cardiac, genitourinary, digestive, ear, nose and throat, and skin manifestations. Patients also have an increased risk of severe infections, developing benign tumors, and immunological abnormalities suggesting primary immunodeficiencies. We report a case of RTS with severe recalcitrant eczema, recurrent skin and chest infections, food allergies associated with a hyper\u2010IgE profile, and other immunological abnormalities, who had a significant response to dupilumab.<\/jats:p>","DOI":"10.1111\/pde.15874","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:19:56Z","timestamp":1738801196000},"page":"826-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rubinstein\u2013Taybi Syndrome With Severe Eczema, Recurrent Infections, and Hyper <scp>IgE<\/scp> Profile Responsive to Dupilumab Treatment"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-3181","authenticated-orcid":false,"given":"Arti","family":"Nanda","sequence":"first","affiliation":[{"name":"As'ad Al\u2010Hamad Dermatology Center  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