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However, these medications are poorly studied in children. In seven children with painful VMs and chronic intravascular consumptive coagulopathy, DOACs allowed for successful pain control and improvement in coagulopathy, with no adverse effects. DOACs appear to be an effective alternative in childhood VM associated with intravascular coagulopathy.<\/jats:p>","DOI":"10.1111\/pde.15930","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T23:51:01Z","timestamp":1744242661000},"page":"1020-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Direct Oral Anti\u2010Coagulants in Painful Venous Malformations in Children"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-2539","authenticated-orcid":false,"given":"Olivia","family":"Boccara","sequence":"first","affiliation":[{"name":"Department of Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), AP\u2010HP Paris University, Necker\u2010Enfants Malades Hospital, Paris Centre University, Imagine Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bonigen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), AP\u2010HP Paris University, Necker\u2010Enfants Malades Hospital, Paris Centre University, Imagine Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Soupre","sequence":"additional","affiliation":[{"name":"Department of Maxillo\u2010Facial and Plastic Surgery Necker Hospital, Paris Centre University, Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Puzenat","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annouk","family":"Bisdorff","sequence":"additional","affiliation":[{"name":"Reference Center for Vascular Anomalies FAVA\u2010Multi University Hospital of Lariboisi\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Drouet","sequence":"additional","affiliation":[{"name":"Anticoagulation Clinic (CREATIF), Cardiology Department Lariboisi\u00e8re Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.7.861"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.7.873"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000412"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13856"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2022.09.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102400"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.06.013"},{"key":"e_1_2_8_9_1","unstructured":"L.DrouetandA.Bisdorff \u201cCoagulation and Thromboembolic Issues Innovation and Futures Trends\u201d (paper presentation 2021 International Society for the Study of Vascular Anomalies Boston Massachusettes USA May 13\u201315 2021)."}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:45:52Z","timestamp":1758725152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/pde.15930"],"URL":"https:\/\/doi.org\/10.1111\/pde.15930","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"2024-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}