{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:05:31Z","timestamp":1764126331607,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification (HO) and congenital malformation of the great toes. This case describes a 5\u2010year\u2010old Caucasian girl who initially presented with painless neck and back swelling as well as severe limitation of movement in the neck and shoulder girdle, who was diagnosed as FOP following tissue\u2010based genetic testing revealing the\n                    <jats:italic>ACVR1<\/jats:italic>\n                    (p.Arg206His) pathogenic variant. The diagnostic process, which included imaging, skin biopsy, and a thorough infectious and autoimmune workup, emphasized the challenges in identifying FOP due to its rarity; however, bilateral congenital hallux valgus, often present in FOP, can be a clue for early diagnosis. While corticosteroids provide temporary relief, long\u2010term management now includes palovarotene, a novel therapy to suppress HO.\n                  <\/jats:p>","DOI":"10.1111\/pde.15962","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T01:43:44Z","timestamp":1748483024000},"page":"1252-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progressive Soft Tissue Swelling in a Pediatric Patient Leading to the Diagnosis of Fibrodysplasia Ossificans Progressiva: A Case Report"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-3229","authenticated-orcid":false,"given":"Orhan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"College of Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-5485","authenticated-orcid":false,"given":"Loretta","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Edmonton Clinic Health Academy University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4655"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20106\u201080"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010010\u20101232\u20105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20101980"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"The Medical Management of Fibrodysplasia Ossificans Progressiva: Current Treatment Considerations","volume":"3","author":"Kaplan F. S.","year":"2024","journal-title":"Proceedings of th International Clinical Council on Fibrodysplasia Ossificans Progressiva"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005\u20100469"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"909","article-title":"Fibrodysplasia Ossificans Progressiva. A Survey of Forty\u2010Two Cases","volume":"61","author":"Rogers J. G.","year":"1979","journal-title":"Journal of Bone and Joint Surgery (American Volume)"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010024\u201003363\u2010y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256\u2010018\u20102889\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4358"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S337491"},{"key":"e_1_2_9_13_1","unstructured":"U.S. Food and Drug Administration \u201cFDA Approves First Treatment for Fibrodysplasia Ossificans Progressiva \u201daccessed September 28 2024 https:\/\/www.fda.gov\/drugs\/news\u2010events\u2010human\u2010drugs\/fda\u2010approves\u2010first\u2010treatment\u2010fibrodysplasia\u2010ossificans\u2010progressiva."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4762"},{"key":"e_1_2_9_15_1","unstructured":"National Library of Medicine \u201cClinicalTrials.gov Search Term: \u2018Fibrodysplasia Ossificans Progressiva\u2019 \u201daccessed February 6 2025 https:\/\/clinicaltrials.gov\/search?cond=Fibrodysplasia%20Ossificans%20Progressiva&viewType=Table."}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:00:30Z","timestamp":1764126030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/pde.15962"],"URL":"https:\/\/doi.org\/10.1111\/pde.15962","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"2024-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}