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It is also used off\u2010label for progressive or metastatic osteosarcoma, which is the most common primary bone malignancy in children and adolescents. While hand\u2010foot skin reaction (HFSR) is a well\u2010documented side effect associated with regorafenib use, no standard guidelines currently exist for preventing and managing regorafenib\u2010associated HFSR in children, or for HFSR and hand\u2010foot syndrome related to other chemotherapy agents. We present a case of regorafenib\u2010induced HFSR in an adolescent with metastatic osteosarcoma that highlights an effective dose\u2010reduction regimen and treatment plan that ultimately resolved her grade 3 HFSR and allowed her to resume alternate anticancer treatment immediately.<\/jats:p>","DOI":"10.1111\/pde.15967","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:34:29Z","timestamp":1747290869000},"page":"1235-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regorafenib\u2010Induced Hand\u2010Foot Skin Reaction in an Adolescent"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5663-0527","authenticated-orcid":false,"given":"Kiera","family":"Murphy","sequence":"first","affiliation":[{"name":"Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bansri","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantelle","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Helm","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State Milton S. 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