{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:17:48Z","timestamp":1789521468279,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) syndrome (OMIM616295) is an exceptionally rare autosomal recessive genodermatosis caused by loss\u2010of\u2010function pathogenic variants in the\n                    <jats:italic>CAST<\/jats:italic>\n                    gene, encoding calpastatin. A total of 19 cases have been described in 12 articles, among families with unique de novo genetic variants of\n                    <jats:italic>CAST.<\/jats:italic>\n                    We describe two pediatric PLACK cases with a homozygous loss\u2010of\u2010function\n                    <jats:italic>CAST<\/jats:italic>\n                    variant (\n                    <jats:italic>c.571G&gt;T<\/jats:italic>\n                    , p.Gly191Ter) which represents the only recurrent genetic variant of PLACK syndrome reported in the literature.\n                  <\/jats:p>","DOI":"10.1111\/pde.15987","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:15:38Z","timestamp":1747646138000},"page":"1239-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis and Knuckle Pads (\n                    <scp>PLACK<\/scp>\n                    ) Syndrome: An Updated Review of Cases and Identification of a Recurrent\n                    <scp>\n                      <i>CAST<\/i>\n                    <\/scp>\n                    Variant in Two Patients"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5148-1115","authenticated-orcid":false,"given":"Fiona","family":"Haxho","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Haber","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janan","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Sarig","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-1032","authenticated-orcid":false,"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Perrier","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Boctor","sequence":"additional","affiliation":[{"name":"University of Calgary and Alberta Children's Hospital, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-3611","authenticated-orcid":false,"given":"Michele","family":"Ramien","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Division of Community Pediatrics, Department of Pediatrics University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660040129027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.434"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2810"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.06.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-019-03077-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13887"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14417"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14383"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13919"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad185"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad167"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1138_2021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16760"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15671"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70140-9"},{"issue":"7","key":"e_1_2_9_19_1","first-page":"662","article-title":"Familial Peeling Skin Syndrome With Eosinophilia: Clinical, Histologic, and Ultrastructural Study of Three Cases","volume":"120","author":"Janin A.","year":"1996","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2006.352"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00102.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.100583"},{"issue":"5","key":"e_1_2_9_23_1","first-page":"255","article-title":"Skin Peeling Syndrome","volume":"53","author":"Tolat S. 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