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There are varying methods of application and treatment regimens among practitioners; a consensus standard of care has yet to be established. This article provides an overview of cantharidin and its role in dermatology with an emphasis on mechanism of action, adverse effects, limitations of use, and how it compares with alternative treatment options. Instructions for topical application and other important considerations surrounding its use are also discussed.<\/jats:p>","DOI":"10.1111\/pde.16000","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:48:22Z","timestamp":1754455702000},"page":"913-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cantharidin: Its Role in Dermatology Revisited"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-9408","authenticated-orcid":false,"given":"Yolanka","family":"Lobo","sequence":"first","affiliation":[{"name":"Department of Dermatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4019-7380","authenticated-orcid":false,"given":"Jessica","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Jibreal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Queensland Children's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.10.1357"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.023"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.2011.01697.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20108741(89)90062\u20107"},{"issue":"6","key":"e_1_2_13_6_1","first-page":"317","article-title":"What's Eating You? 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