{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T15:21:34Z","timestamp":1769786494959,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Generalized pustular psoriasis is uncommon in children and therapy is typically with systemic agents. While many drugs like oral retinoids, cyclosporine, methotrexate, and spesolimab are used, colchicine is a safe and underutilized drug that acts by inhibition of neutrophils and the TNF\u2010\u03b1\u2010NF\u2010k\u03b2 pathway. We report a case of a 10\u2010year\u2010old with generalized pustular psoriasis refractory to cyclosporine and methotrexate who achieved complete remission within 6\u2009weeks of colchicine monotherapy.<\/jats:p>","DOI":"10.1111\/pde.16024","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:54:47Z","timestamp":1756382087000},"page":"211-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Generalized Pustular Psoriasis Responsive to Colchicine: A Cost\u2010Effective Alternative to Biologics"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-8964","authenticated-orcid":false,"given":"Savitha","family":"Sharath","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1757-3406","authenticated-orcid":false,"given":"Kabir","family":"Sardana","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0644-3294","authenticated-orcid":false,"given":"Aakanksha","family":"Marmat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2484-462X","authenticated-orcid":false,"given":"Arunesh Padmini","family":"Kathirvelu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Paliwal","sequence":"additional","affiliation":[{"name":"Department of Pathology Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.072"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12351"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_475_20"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403737"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14959"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.16024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.16024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.16024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:29:24Z","timestamp":1769736564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.16024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pde.16024"],"URL":"https:\/\/doi.org\/10.1111\/pde.16024","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}