{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:03:01Z","timestamp":1788778981713,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Significant gaps exist in the literature regarding the work\u2010up and management of staphylococcal scalded skin syndrome (SSSS). These include (a) the utility of ancillary testing in improving diagnostic accuracy and informing patient care, and (b) appropriate management strategies for antibiotics, fluids, and skin care. Moreover, no systematic review to date has focused on non\u2010neonatal pediatric SSSS to provide a comprehensive analysis of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of PubMed and OVID was conducted from 2010 to 2024 using the medical subject heading (MeSH) term \u2018staphylococcal scalded skin syndrome\u2019 with restriction to MeSH major topic. Studies involving neonates (&lt;\u200990\u2009days old) and premature infants (&lt;\u200937\u2009weeks' gestation) were excluded. Articles were limited to English\u2010language studies involving human subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 studies were analyzed. Laboratory evaluations, including blood counts, chemistry panels, and inflammatory markers, were found to be non\u2010specific and did not enhance diagnostic accuracy or inform patient care. Aerobic bacterial cultures from suspected infection foci were more likely to yield positive results, while blood cultures were typically sterile. Findings suggest that clindamycin does not improve outcomes in SSSS, supporting beta\u2010lactam antibiotics as a preferred first\u2010line treatment. Fluid resuscitation was necessary for children unable to maintain oral intake, and bland emollients were effective for skin care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings support a \u201cless is more\u201d approach to both the work\u2010up and management of SSSS, emphasizing minimal laboratory testing, targeted antibiotic use, and supportive skin care. Future research should focus on prospective studies implementing these strategies and evaluating outcomes to refine care further.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.16029","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T08:54:16Z","timestamp":1752310456000},"page":"978-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pediatric Staphylococcal Scalded Skin Syndrome: A Systematic Review of the Literature to Inform Work\u2010Up and Management"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-1420","authenticated-orcid":false,"given":"Laurel","family":"Gray","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-5473","authenticated-orcid":false,"given":"Annika M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Spencer Fox Eccles School of Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-1458","authenticated-orcid":false,"given":"Sarah D.","family":"Cipriano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"3","article-title":"Die Exfoliativa Dermatitis Jjungerer Saulinge","volume":"2","author":"Rittershain G. R.","year":"1878","journal-title":"Centralz Kinderhheilk"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.02.029"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197005142822002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(88)96249-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1890-1893.2005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7760-7771.2001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2000.tb02481.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb41501.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00085.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/81385"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.1007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16097"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.023"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19691"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12114"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.08.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12053"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000373"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01120-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10515.x"},{"issue":"4","key":"e_1_2_10_22_1","first-page":"417","article-title":"Demographic and Clinical Characteristics and Risk Factors for Staphylococcal Scalded Skin Syndrome in Hunan","volume":"41","author":"Su J.","year":"2016","journal-title":"Zhong Nan Da Xue Xue Bao. Yi Xue Ban"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14629"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.09.041"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2018-0206"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NURSE.0000504683.43755.18"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002564"},{"key":"e_1_2_10_28_1","volume-title":"UpToDate","author":"Patrick M. M.","year":"2024"},{"key":"e_1_2_10_29_1","first-page":"1273","volume-title":"Dermatology","author":"McLarney R. M.","year":"2024"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31828e89f5"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14116"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-018-0150-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14470"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15102"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2018-0032"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e22"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TME.0000000000000235"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2015.06.021"},{"issue":"1","key":"e_1_2_10_39_1","first-page":"220","article-title":"Presentation and Management of Staphylococcal Scalded Skin Syndrome in a Child After a Burn Injury: A Case Report","volume":"41","author":"Pidgeon T. E.","year":"2020","journal-title":"Journal of Burn Care & Research"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20100922-02"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.06.033"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.10.013"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200009000-00002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15027"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14014"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57111157"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0018578718760257"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39372.829676.47"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.05.035"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/510396"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.2996-3003.2001"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00120-16"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.3529"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12195"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002499"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-018-0291-8"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.02.006"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00406-17"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0927-x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12541"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00347.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116240"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.044"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2051148"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2008.01316.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.16029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:45:48Z","timestamp":1758725148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.16029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,12]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/pde.16029"],"URL":"https:\/\/doi.org\/10.1111\/pde.16029","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,12]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}