{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:04:12Z","timestamp":1769789052750,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Keratitis\u2013ichthyosis\u2013deafness (KID) syndrome is a rare genetic condition typically presenting at birth with ichthyosiform erythroderma and bilateral hearing loss and later progressing to diffuse keratodermatous plaques with scaling. The condition is associated with mutations in the\n                    <jats:italic>GJB2<\/jats:italic>\n                    gene, which lead to aberrant activation of connexin hemichannels in keratinocytes. While no targeted treatment currently exists, a previously published in\u00a0vivo study demonstrated that flufenamic acid (FFA), a nonspecific connexin inhibitor, reduces epidermal pathology in transgenic mouse models expressing the lethal\n                    <jats:italic>GJB2<\/jats:italic>\n                    mutation. Herein, we report the case of a 5\u2010year\u2010old boy with KID syndrome presenting with painful, persistent scalp lesions, which responded remarkably well to topical mefenamic acid, offering a potential novel therapy for managing this challenging condition.\n                  <\/jats:p>","DOI":"10.1111\/pde.70000","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:24:35Z","timestamp":1755242675000},"page":"145-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Epidermal Pathology in a Pediatric Patient With Keratitis\u2013Ichthyosis\u2013Deafness (\n                    <scp>KID<\/scp>\n                    ) Syndrome With\u00a0Topical Mefenamic Acid"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-6137","authenticated-orcid":false,"given":"Radhika","family":"Gupta","sequence":"first","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Changi General Hospital  Simei Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brichta","sequence":"additional","affiliation":[{"name":"Chemistry Rx Compounding and Specialty Pharmacy  Folcroft Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-8780","authenticated-orcid":false,"given":"Albert C.","family":"Yan","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Dermatology Section Children's Hospital of Philadelphia  Philadelphia Pennsylvania 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