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We present a challenging case of multifocal KHE on the leg of an infant, initially suspected at birth to be a reticulate port wine birthmark. Skin biopsy and imaging supported the rare diagnosis of multifocal KHE. Complicated by KMP, he was started on sirolimus monotherapy with significant improvement in his widespread disease.<\/jats:p>","DOI":"10.1111\/pde.70003","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T03:14:03Z","timestamp":1755486843000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifocal Kaposiform Hemangioendothelioma Successfully Treated With Sirolimus Monotherapy"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-9607","authenticated-orcid":false,"given":"Matthew J.","family":"Mahoney","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin P.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology 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