{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:56:21Z","timestamp":1780631781207,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Two 4\u2010week, phase 2, open\u2010label, maximal usage pharmacokinetic (PK) and safety studies of once\u2010daily roflumilast cream 0.3% (a potent phosphodiesterase 4 inhibitor) were conducted in children aged 2\u20135\u2009years and 6\u201311\u2009years with psoriasis. Evidence of systemic exposure to roflumilast and its active N\u2010oxide metabolite was seen in most patients following daily application, consistent with previous studies. Under maximal use conditions, once\u2010daily roflumilast cream 0.3% was well tolerated and improved signs and symptoms of psoriasis in children aged 2\u201311\u2009years, consistent with phase 3 results in adults and adolescents.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Clinicaltrials.gov listing: 215: NCT04655313; 216: NCT04746911.\n                  <\/jats:p>","DOI":"10.1111\/pde.70013","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:09:44Z","timestamp":1756300184000},"page":"105-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in\u00a0Children Aged 2\u201311\u2009Years"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-5729","authenticated-orcid":false,"given":"Adelaide A.","family":"Hebert","sequence":"first","affiliation":[{"name":"UTHealth McGovern Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen V.","family":"Guide","sequence":"additional","affiliation":[{"name":"Children's Hospital of Orange County  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlada","family":"Groysman","sequence":"additional","affiliation":[{"name":"Cahaba Dermatology &amp; Skin Health Center  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes E.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Pediatric Skin Research, LLC  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Blanco","sequence":"additional","affiliation":[{"name":"Instituto Dermatologico  Santa Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Laquer","sequence":"additional","affiliation":[{"name":"First OC Dermatology Research  Fountain Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Seal","sequence":"additional","affiliation":[{"name":"Arcutis Biotherapeutics Inc.  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