{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:56:00Z","timestamp":1775883360449,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>With the increasing use of continuous glucose monitors and continuous subcutaneous insulin infusion (CSII) devices in pediatric patients with type 1 diabetes (T1DM), dermatologic complications are being reported more frequently. We describe four children with T1DM who developed persistent erythematous nodules with suppurative granulomatous inflammation at prior CSII injection sites. Treatment responses varied: one child improved after transitioning to subcutaneous insulin injections, another with oral dapsone, a third after switching CSII devices and limiting placement to the abdomen, and a fourth with topical corticosteroids and antibiotic ointment. This rare complication appears unrelated to specific device models or insulin types, highlighting the need for further studies to identify risk factors and guide optimal management.<\/jats:p>","DOI":"10.1111\/pde.70030","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:22:07Z","timestamp":1759958527000},"page":"415-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Subcutaneous Insulin Infusion (\n                    <scp>CSII<\/scp>\n                    )\u2010Associated Granulomatous Suppurative Reaction in\u00a0Four Children With Type 1 Diabetes"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3293-8949","authenticated-orcid":false,"given":"Sarah","family":"Lee","sequence":"first","affiliation":[{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-7967","authenticated-orcid":false,"given":"Valerie M.","family":"Carlberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Division of Pediatric Dermatology Children's Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Todd","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Norton Children's Medical Group  Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta A. R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4553-1927","authenticated-orcid":false,"given":"Anna Cristina","family":"Garza\u2010Mayers","sequence":"additional","affiliation":[{"name":"Division of Dermatology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-5807","authenticated-orcid":false,"given":"Tina","family":"Ho","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296820918894"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.10.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110922"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0142"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12652"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19908"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2196\/59824"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13429"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108089"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14438"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20100897"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:26:27Z","timestamp":1775881587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/pde.70030"],"URL":"https:\/\/doi.org\/10.1111\/pde.70030","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}