{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:43:27Z","timestamp":1785300207169,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Purpura fulminans (PF) is a rare, often fatal pediatric condition characterized by intravascular thrombosis and hemorrhagic infarction of the skin. A timely diagnosis and treatment are paramount to prevent the involvement of internal organs, causing disseminated intravascular coagulation and gangrene of the extremities. The management of PF requires a comprehensive approach, including the treatment of the underlying infection, anticoagulation, and anti\u2010inflammatory therapy. Herein we present the case of a child with severe PF successfully treated with anakinra, an anti\u2010IL1\u2010receptor monoclonal antibody.<\/jats:p>","DOI":"10.1111\/pde.70034","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:22:08Z","timestamp":1759958528000},"page":"421-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Treatment of Severe Purpura Fulminans With Anakinra"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-3485","authenticated-orcid":false,"given":"Francesco","family":"Zulian","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Padova University Hospital  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-8525","authenticated-orcid":false,"given":"Luca","family":"Spiezia","sequence":"additional","affiliation":[{"name":"Department of Medicine Padova University Hospital  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4286-1006","authenticated-orcid":false,"given":"Antonio","family":"Amabile","sequence":"additional","affiliation":[{"name":"Clinic of Plastic Surgery University Hospital of Padua  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-4059","authenticated-orcid":false,"given":"Francesca","family":"Tirelli","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Padova University Hospital  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Meneghel","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Padova University Hospital  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.199919"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.923266"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.v27.i3.30"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-019-0168-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001150"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Fatal Purpura Fulminans and Waterhouse\u2010Friderichsen Syndrome From Fulminant \n                     Streptococcus pneumoniae\n                   Sepsis in an Asplenic Young Adult","volume":"6","author":"Hale A. 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