{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:54:27Z","timestamp":1772549667527,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proteus syndrome (PS) is a rare genetic disorder caused by mosaic\n                    <jats:italic>AKT1<\/jats:italic>\n                    mutations, leading to progressive and asymmetric overgrowth. We report a mildly symptomatic 12\u2010year\u2010old male with left lower limb overgrowth and an epidermal nevus, whose diagnosis was confirmed through molecular diagnostics. Targeted NGS identified the pathogenic\n                    <jats:italic>AKT1<\/jats:italic>\n                    c.49G&gt;A mutation in affected tissues, supporting the diagnosis despite the absence of hallmark features like cerebriform connective tissue nevus. This case highlights the importance of genetic testing in subtle presentations of PS, enabling early diagnosis, monitoring, and intervention to mitigate potential complications.\n                  <\/jats:p>","DOI":"10.1111\/pde.70035","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:45:07Z","timestamp":1756964707000},"page":"214-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of a Mild and Atypical Presentation of Proteus Syndrome"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-7695","authenticated-orcid":false,"given":"Camilo E.","family":"Alarc\u00f3n\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3 de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Department of Dermatology Hospital Sant Joan de D\u00e9u  Barcelona 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