{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:05:34Z","timestamp":1764126334115,"version":"3.46.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Children with atopic dermatitis (AD) frequently experience sleep disturbances. Melatonin, an over\u2010the\u2010counter supplement, is increasingly used in the general pediatric population; however, its prevalence and perceived effectiveness in children with AD remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Caregivers of pediatric patients (ages 1\u201317 years) with physician\u2010diagnosed AD completed surveys on melatonin use, Patient Oriented Eczema Measure (POEM), and age\u2010appropriate sleep questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 102 total respondents, 27.5% reported a history of melatonin use, with 10.8% using it in the past 30\u2009days. Gummies were the most common formulation (85.7%), though brands and dosages varied widely (0.5\u201310\u2009mg; median: 3\u2009mg). 32.1% of caregivers initiated melatonin based on a healthcare professional's recommendations, while the majority initiated use independently (50.0%) or based on recommendations from friends\/family (21.4%) or online resources (7.1%). Melatonin use was significantly more common among children with behavioral or psychological comorbidities compared to those without (56.3% vs. 22.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Children ages 6\u201017 who used melatonin had significantly higher PROMIS Sleep Disturbance scores than nonusers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Perceived effectiveness varied: for sleep, 21.4% of caregivers found melatonin very useful, 32.1% somewhat useful, and 39.3% of little or no use. For nocturnal itch, 14.3% found melatonin very useful, 17.9% somewhat useful, and 50.0% of little or no use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a high prevalence of melatonin use among children with AD. Most caregivers are initiating melatonin independently, and dosage varies widely. Given mixed caregiver\u2010reported effectiveness of melatonin and limited long\u2010term safety data, it is imperative that further studies are performed to evaluate melatonin's role in children with AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70041","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T01:48:19Z","timestamp":1757468899000},"page":"1156-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Use of Melatonin in Children With Atopic Dermatitis: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3293-8949","authenticated-orcid":false,"given":"Sarah","family":"Lee","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-6283","authenticated-orcid":false,"given":"Eun Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"LeBovidge","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itohan","family":"Aigbekaen","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Berbert","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Schneider","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-5807","authenticated-orcid":false,"given":"Tina","family":"Ho","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.0025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.01.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666161228122115"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Use of Complementary Health Approaches Among Children Aged 4\u201317\u2009Years in the United States: National Health Interview Survey, 2007\u20132012","volume":"78","author":"Black L. I.","year":"2015","journal-title":"National Health Statistics Reports"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2023.4749"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7122a1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2296"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3823"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040462"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.3092"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12978"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.138"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.12502"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.12.018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010079X.2009.00681.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.09.414"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S193891"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010019\u20101835\u20101"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010079x.2003.02931.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare6010023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S181365"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2018.07.005"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:00:33Z","timestamp":1764126033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/pde.70041"],"URL":"https:\/\/doi.org\/10.1111\/pde.70041","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}