{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:42:57Z","timestamp":1787164977481,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic pustular folliculitis (EPF) is a rare, noninfectious eosinophilic inflammatory disease that manifests with papulopustular lesions. Although EPF is not a severe skin disorder, it is recurring and causes uncomfortable symptoms, such as itching, that impact the patient's quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The Embase, PubMed, Web of Science, and Cochrane databases were systematically searched for studies on children with EPF up to May 2025. The study was performed according to Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. A restricted maximum likelihood (REML) random\u2010effects model was performed for all endpoints to synthesize results with a 95% confidence interval (CI). Cochran's\n                      <jats:italic>Q<\/jats:italic>\n                      test and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      were used to assess heterogeneity. R version 4.2.2 was used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>52 studies comprising 136 patients with EPF were included. The analysis showed a mean age of 11.16\u2009months (95% CI: 5.11\u201317.22) and a male predominance of 80.58% (95% CI: 71.60\u201388.20). Scalp lesions were the most common site with a rate of 92.10% (95% CI: 71.25\u2013100.00). The most common treatment included topical hydrocortisone at 1.48% (95% CI: 0.00\u20138.51), corticoid not identified (NI) at 2.00% (95% CI: 0.00\u20139.42), and others at 6.17% (95% CI: 0.00\u201324.16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis showed that EPF in childhood primarily affects male patients, with patient ages ranging from 0.03 to 192\u2009months. The lesion's most frequent location is the scalp. Corticosteroids were identified as the primary treatment strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70060","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:34:12Z","timestamp":1764578052000},"page":"310-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Treatment of Eosinophilic Pustular Folliculitis in Childhood: A Systematic Review and Single\u2010Arm Meta\u2010Analysis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0788-130X","authenticated-orcid":false,"given":"Beatriz Ximenes","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Medicine Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1127-230X","authenticated-orcid":false,"suffix":"Jr.","given":"Vanio L.","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Health Sciences of Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-2115","authenticated-orcid":false,"given":"Lucas M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-5616","authenticated-orcid":false,"given":"Maria L. R.","family":"Defante","sequence":"additional","affiliation":[{"name":"Department of Medicine Redentor University Center  Itaperuna Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7345-0751","authenticated-orcid":false,"given":"Beatriz A. A. H.","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Medicine Cesmac University Center  Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina Rodriguez","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine Cesmac University Center  Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-4582","authenticated-orcid":false,"given":"Pedro","family":"Romeiro","sequence":"additional","affiliation":[{"name":"Department of Medicine University Center of Macei\u00f3, UNIMA  Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrina Rezende","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Vi\u00e7osa  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5672-2649","authenticated-orcid":false,"given":"Lilia Maria Lima","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Principles and Practice of Clinical Research (PPCR)\u2014Post\u2010Graduate Program Harvard T.H. 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