{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:56:14Z","timestamp":1775883374255,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a rare case of a 12\u2010year\u2010old girl with the coexistence of hidradenitis suppurativa (HS) and hyperimmunoglobulin D syndrome (HIDS), harboring a homozygous\n                    <jats:italic>MVK<\/jats:italic>\n                    V377I mutation and compound heterozygous\n                    <jats:italic>MEFV<\/jats:italic>\n                    mutations, both classified as pathogenic. Despite a partial response to adalimumab and anakinra, complete remission of both febrile episodes and HS lesions was achieved with canakinumab therapy. This case emphasizes the importance of IL\u20101\u03b2\u2010mediated inflammation in the pathogenesis of syndromic HS and highlights the role of multigenic contributions. Early recognition and targeted treatment may improve outcomes in patients with overlapping autoinflammatory conditions.\n                  <\/jats:p>","DOI":"10.1111\/pde.70063","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:28:48Z","timestamp":1759732128000},"page":"398-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare Coexistence of Hidradenitis Suppurativa and Hyper\u2010\n                    <scp>IgD<\/scp>\n                    Syndrome With Homozygous\n                    <scp>\n                      <i>MVK<\/i>\n                      V377I\n                    <\/scp>\n                    and Compound Heterozygous\n                    <scp>\n                      <i>MEFV<\/i>\n                    <\/scp>\n                    (\n                    <scp>M680I<\/scp>\n                    \/\n                    <scp>E148Q<\/scp>\n                    ) Mutations"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-1531","authenticated-orcid":false,"given":"Gamze","family":"Tas\u2010Aygar","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Health Sciences Etlik City Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-2175","authenticated-orcid":false,"given":"M\u00fczeyyen","family":"G\u00f6n\u00fcl","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Health Sciences Etlik City Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2341","authenticated-orcid":false,"given":"Emine Nur","family":"Sunar Yayla","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Clinic University of Health Sciences Etlik City Hospital  Ankara 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