{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:58:40Z","timestamp":1787500720095,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vitiligo is an autoimmune condition that causes depigmented skin patches, often leading to challenges such as stigma, bullying, and poor self\u2010esteem in pediatric populations. These challenges may contribute to psychiatric comorbidities and impaired quality of life (QoL). Pediatric\u2010specific data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To synthesize current evidence on psychiatric comorbidities and QoL outcomes in pediatric vitiligo and identify factors associated with increased psychosocial burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, and MEDLINE were systematically searched through March 15, 2025, for primary English\u2010language studies involving patients aged 0\u201318\u2009years with vitiligo and validated psychiatric or QoL outcomes. Study quality was assessed using Oxford Centre for Evidence\u2010Based Medicine Levels of Evidence. Meta\u2010analyses were performed where possible, with 95% confidence intervals and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      for heterogeneity. Certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation framework.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091576) were included. Pooled means for depression (CDI: 9.93) and anxiety scores (STAI\u2010State: 37.07; STAI\u2010Trait: 38.27) did not exceed thresholds for probable clinical diagnosis, though heterogeneity was considerable. Pooled means for QoL burden (CDLQI: 3.00; PedsQL: 80.55) suggested mild\u2010to\u2010moderate QoL impairment. Multiple individual comparative studies reported greater psychiatric symptom burden and higher prevalence of depression and anxiety among vitiligo patients versus controls. Subgroup findings from selected studies also suggested worse QoL in adolescents and those with extensive or visible lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pediatric vitiligo is associated with elevated psychiatric comorbidity prevalence, symptom burden, and mild\u2010to\u2010moderate QoL impairment among included studies. These findings highlight the need for clinicians to integrate psychosocial assessment into routine care. Current evidence further emphasizes incorporating routine mental health screening and multidisciplinary support into pediatric dermatology practice for children with vitiligo, although conclusions are restricted by limited and heterogeneous data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70066","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:53:27Z","timestamp":1760417607000},"page":"64-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psychiatric Comorbidities and Quality\u2010of\u2010Life Burden in Pediatric Patients With Vitiligo: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9968-9367","authenticated-orcid":false,"given":"Nawar","family":"Tarafdar","sequence":"first","affiliation":[{"name":"Western University, Schulich School of Medicine and Dentistry  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Varambally","sequence":"additional","affiliation":[{"name":"Western University, Schulich School of Medicine and Dentistry  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-5661","authenticated-orcid":false,"given":"Elena","family":"Pope","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3369","authenticated-orcid":false,"given":"Joseph M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-0116","authenticated-orcid":false,"given":"Chaocheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia 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