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LOCS phenotype includes cutaneous, ocular, and laryngeal granuloma formation and scarring. Management relies on multidisciplinary symptomatic care, and successful disease\u2010modifying therapies are infrequently documented. Here, we describe a 7\u2010year\u2010old female with characteristic manifestations of LOCS who has had a significant response to oral thalidomide.<\/jats:p>","DOI":"10.1111\/pde.70069","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:31:03Z","timestamp":1759743063000},"page":"402-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngo\u2010Onycho\u2010Cutaneous Syndrome Managed With Thalidomide"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-7173","authenticated-orcid":false,"given":"Ellen","family":"Chinchilli","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Cordisco","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"E. 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W. H. C.","year":"2021","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(85)70014\u2010x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.10.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5173"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.152580"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.002"},{"issue":"3","key":"e_1_2_7_22_1","first-page":"194","article-title":"Management of Thalidomide Toxicity","volume":"1","author":"Ghobrial I. 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