{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T19:02:50Z","timestamp":1779649370600,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Chediak\u2013Higashi syndrome (\n CHS<\/jats:styled-content>\n ) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (\n HLH<\/jats:styled-content>\n ), which significantly worsens prognosis. We report the case of a 19\u2010year\u2010old male with\n CHS<\/jats:styled-content>\n , under long\u2010term immunosuppressive therapy for chronic\n HLH<\/jats:styled-content>\n , who developed chronic\n VZV<\/jats:styled-content>\n infection. Despite treatment with valacyclovir, the lesions progressed, and virological investigations confirmed the diagnosis of acyclovir\u2010resistant varicella\u2010zoster virus (\n VZV<\/jats:styled-content>\n ). The clinical course was marked by the appearance of neurological symptoms and a fatal outcome. To our knowledge, this is the first reported fatal case of chronic\n VZV<\/jats:styled-content>\n infection with systemic dissemination in a patient with\n CHS<\/jats:styled-content>\n . This case highlights the risk of resistance associated with long\u2010term prophylaxis and the complexity of managing herpesvirus infections in immunocompromised patients receiving\n JAK<\/jats:styled-content>\n inhibitors.\n <\/jats:p>","DOI":"10.1111\/pde.70082","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:54:50Z","timestamp":1763628890000},"page":"706-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fatal Chronic Varicella\u2010Zoster Viral Infection in a Young Man With Chediak\u2013Higashi Syndrome"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7974-5861","authenticated-orcid":false,"given":"Albane","family":"Badet","sequence":"first","affiliation":[{"name":"Department of Dermatology Lille University Hospital Lille France"},{"name":"University of Lille Lille 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