{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:56:39Z","timestamp":1775883399978,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hematopoietic stem cell transplantation (HSCT) is associated with several dermatological adverse events, including the de novo onset of pruritus and eczema. Some authors consider this a variant of graft\u2010versus\u2010host disease (GvHD) and refer to it as eczematous or atopic dermatitis (AD)\u2010like GvHD, while others categorize it separately as eczematous or AD\u2010like dermatitis. This study aimed to report a pediatric case series and review previously published cases treated with dupilumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicenter study including patients aged 0\u201318 treated with dupilumab for new eczematous lesions following HSCT up to 2024 in three tertiary hospitals in Spain. A literature review in PubMed identified all reported pediatric and adult cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 24 cases were identified: 9 from our centers and 15 from the literature. Median onset was 3\u2009months post\u2010HSCT. All patients presented with pruritus and eczema. 47% showed flexural involvement. Histology revealed eczematous features in 73%, mixed GvHD\/eczema in 20%, and pure GvHD in 7%. 38% were classified as post\u2010HSCT eczema, and 63% as eczematous or AD\u2010like GvHD. All were refractory to topical corticoids and different systemic immunosuppressants. Dupilumab led to complete or near\u2010complete resolution in 96% of cases. No serious adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dupilumab appears to be effective and safe for eczematous lesions occurring after HSCT, regardless of whether the histopathological characteristics align with eczema or GvHD. This supports a shared spectrum between eczematous dermatitis and GvHD, and the use of a neutral diagnostic term. Further research is needed to clarify its pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70084","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:35:56Z","timestamp":1763627756000},"page":"289-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010Hematopoietic Stem Cell Transplantation Eczematous Dermatitis Spectrum Successfully Treated With Dupilumab: A Case Series and Review of the Literature"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0694-4757","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Rodr\u00edguez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-2265","authenticated-orcid":false,"given":"Minia","family":"Campos\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0640-2200","authenticated-orcid":false,"given":"Antonio","family":"del Alcal\u00e1\u2010Ram\u00edrez del Puerto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Bernabeu\u2010Wittel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Monserrat\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Arias\u2010Lotto","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Parra\u2010Blanco","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bel\u00e9ndez\u2010Bieler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Garc\u00eda\u2010Mor\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7818-3463","authenticated-orcid":false,"given":"Eduardo","family":"Bard\u00f3n\u2010Cancho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"Marco\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Gonz\u00e1lez\u2010Gerrero","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8439","authenticated-orcid":false,"given":"Eul\u00e0lia","family":"Baselga\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Prat\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13836"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.04.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.07.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.12.305"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.11.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14653"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.08.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad526"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000003018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010023\u201001525\u20104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15146"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010021\u201001157\u20106"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2004.06072.x"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"51","article-title":"Eczema\u2010Like Cutaneous Graft Versus Host Disease Treated by UV\u2010B Therapy in a 2\u2010Year\u2010Old Child","volume":"126","author":"Tanasescu S.","year":"1999","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.9.1157"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.12.970"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.207475"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.12.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13400"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201005\u20101775"},{"issue":"3","key":"e_1_2_8_24_1","first-page":"109","article-title":"Atopic Dermatitis Induced by Systemic Immunosupression With Tacrolimus\u2014Case Report","volume":"45","author":"Bumbacea R. S.","year":"2013","journal-title":"European Annals of Allergy and Clinical Immunology"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15280"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16349"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:27:29Z","timestamp":1775881649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/pde.70084"],"URL":"https:\/\/doi.org\/10.1111\/pde.70084","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}