{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T19:02:50Z","timestamp":1779649370655,"version":"3.53.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    (NHPH) species are gram\u2010negative, microaerophilic, spiral\u2010shaped bacteria that can rarely cause recurrent bacteremia, cellulitis, and pyoderma gangrenosum\u2010like ulcers, particularly in immunocompromised individuals such as those with X\u2010linked agammaglobulinemia (XLA). We present a case of a 21\u2010year\u2010old male with XLA who presented with painful, recurrent, firm, indurated cutaneous plaques on the upper and lower extremities, initially suspected to have eosinophilic fasciitis. Diagnosis of NHPH bacteremia was confirmed using both 16S rRNA sequencing and the Karius test, a plasma\u2010based next\u2010generation sequencing platform that detects microbial cell\u2010free DNA, and symptoms resolved after successful treatment of the organism. This case raises awareness for NHPH\u2010induced fasciitis in the differential diagnosis of painful, recurrent atypical, indurated plaques in patients with XLA.\n                  <\/jats:p>","DOI":"10.1111\/pde.70099","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:33:51Z","timestamp":1763634831000},"page":"702-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enterohepatic Non\u2010\n                    <i>H. pylori Helicobacter<\/i>\n                    Infection in a Patient With X\u2010Linked Agammaglobulinemia"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-9838","authenticated-orcid":false,"given":"Hannah R.","family":"Chang","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-1738","authenticated-orcid":false,"given":"Daniel","family":"Whitehurst","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P.","family":"Schlaudecker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Karunakaran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerith E.","family":"Spicknall","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-5659","authenticated-orcid":false,"given":"Catherine","family":"Bridges","sequence":"additional","affiliation":[{"name":"Division of Dermatology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.807136"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010024\u201001668\u2010y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00265\u201014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.06.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010020\u201000830\u20106"},{"key":"e_1_2_6_6_2","unstructured":"Published Correction Appears in J Clin Immunol. 2021;41(4):847.https:\/\/doi.org\/10.1007\/s10875\u2010021\u201001015\u20105."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.11.016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010022\u201001237\u20101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19766.4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy114"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T18:19:46Z","timestamp":1779646786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pde.70099"],"URL":"https:\/\/doi.org\/10.1111\/pde.70099","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}