{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T19:02:46Z","timestamp":1779649366858,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Elexacaftor\/tezacaftor\/ivacaftor is a novel \u201ctriple therapy\u201d drug which has been shown in clinical trials to reduce morbidity\u00a0and\u00a0mortality in cystic fibrosis patients. Few reports of serious cutaneous adverse reactions to elexacaftor\/tezacaftor\/ivacaftor leading to drug discontinuation have been previously documented, all occurring within 1 month of drug initiation. Herein we present a novel case of delayed bullous drug eruption, arising 2\u2009years after elexacaftor\/tezacaftor\/ivacaftor\u00a0initiation, with subsequent successful drug re\u2010introduction. Documentation of the possible serious cutaneous adverse effects of elexacaftor\/tezacaftor\/ivacaftor will importantly aid understanding of the potential for drug re\u2010challenge in these cases.<\/jats:p>","DOI":"10.1111\/pde.70110","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:27:17Z","timestamp":1766993237000},"page":"724-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Delayed Bullous Drug Eruption Induced by Elexacaftor\/Tezacaftor\/Ivacaftor"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-1123","authenticated-orcid":false,"given":"Tatiana","family":"Ninkov","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Yap","sequence":"additional","affiliation":[{"name":"Perth Children's Hospital  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima Mesbah","family":"Ardakani","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology PathWest, QEII Medical Centre  Nedlands Australia"},{"name":"School of Medicine, The University of Notre Dame, Fremantle Campus  Fremantle Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Le Souef","sequence":"additional","affiliation":[{"name":"Perth Children's Hospital  Nedlands Australia"},{"name":"School of Medicine, The University of Western Australia  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-243X","authenticated-orcid":false,"given":"Kurt","family":"Gebauer","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Western Australia  Nedlands Australia"},{"name":"Fremantle Dermatology  Fremantle Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Foster","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital  Nedlands Australia"},{"name":"Perth Children's Hospital  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142532"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4116"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.10.018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5070\/D368K916PH"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02029-2022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25437"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-247042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-27.5.463"},{"issue":"9","key":"e_1_2_8_12_1","article-title":"Triple Therapy for Cystic Fibrosis (Elexacaftor, Tezacaftor, and Ivacaftor): Desensitization After Skin Rash","volume":"15","author":"Santos A. I.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.08.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13787"},{"issue":"10","key":"e_1_2_8_15_1","article-title":"Fixed Drug Eruption Secondary to Four Anti\u2010Diabetic Medications: An Unusual Case of Polysensitivity","volume":"13","author":"Al Masri D.","year":"2021","journal-title":"Cureus"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T18:19:32Z","timestamp":1779646772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,28]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pde.70110"],"URL":"https:\/\/doi.org\/10.1111\/pde.70110","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,28]]},"assertion":[{"value":"2025-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}