{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:06:45Z","timestamp":1789571205546,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genodermatosis characterized by skin fragility and systemic complications, including anemia, inflammation, and nutritional deficiencies. The prevalence and age of onset of monitoring laboratory tests remain poorly defined in the current literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the frequency of nutritional deficiencies and earliest age of laboratory abnormalities in a cohort of RDEB patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of 122 patients with RDEB seen at a tertiary care EB center (2010\u20132021) was conducted. Laboratory and anthropometric data from initial visits were stratified by age group and compared to institutional reference ranges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Inflammatory markers were frequently elevated: C\u2010reactive protein (CRP) (100%, 74\/74) and ESR (81%, 71\/88), including in patients &lt;\u20092\u2009years. Anemia (86%, 98\/114) and iron deficiency (84%, 80\/95) were highly prevalent. Hypoalbuminemia was present in 69% of patients (77\/112), particularly among those younger than 16\u2009years. Thrombocytosis occurred in 41% (49\/120). Anthropometric measures revealed early declines in weight\u2010for\u2010age and height\u2010for\u2010age percentiles and persistently low BMI. Mean height\u2010for\u2010age percentile decreased sharply from the 61st to the 30th %ile between ages 0\u20131.99 and 2\u20133.99\u2009years. Vitamin D deficiency (using a 30\u2009ng\/mL cutoff) affected 49% (44\/90), especially those &gt;\u20098\u2009years. Zinc and carnitine levels declined with increasing age, but the majority of patients had values within normal limits. Magnesium, selenium, phosphorus, and thyroid studies were within normal limits for most patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nutritional, hematologic, and inflammatory abnormalities are common and often present, even in infancy, among patients with RDEB. These findings underscore the need for standardized, age\u2010specific laboratory monitoring protocols beginning in early childhood. Early recognition of and intervention for abnormalities may improve long\u2010term outcomes in this medically complex population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70130","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:58:35Z","timestamp":1788537515000},"page":"62-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Single Center Retrospective Chart Review of Monitoring Laboratory Tests in Recessive Dystrophic Epidermolysis Bullosa"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-3665","authenticated-orcid":false,"given":"Daniel P.","family":"Ashley","sequence":"first","affiliation":[{"name":"Department of Medicine University of Louisville  Louisville Kentucky 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