{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:28:48Z","timestamp":1782300528157,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Stevens\u2010Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life\u2010threatening mucocutaneous reactions. Pediatric mortality is lower than in adults, but children face higher risks of recurrence and long\u2010term sequelae. Despite disease severity, pediatric\u2010specific guidelines remain scarce and often extrapolated from adult populations. We systematically reviewed and appraised national and international clinical practice guidelines and consensus statements on pediatric SJS\/TEN, focusing on supportive care, pharmacologic interventions, mucosal management, and long\u2010term follow\u2010up. A systematic search of MEDLINE, Embase, PubMed, CENTRAL, Scopus, and CINAHL (January 2000\u2013April 2025) identified national and international guidelines. For feasibility, we restricted full appraisal to documents published in English or French. Eligible documents provided explicit recommendations for patients &lt;\u200918\u2009years. Two reviewers independently extracted data and assessed quality using the AGREE II instrument. Of 144 records screened, 10 guidelines met inclusion criteria; 60% were published within the last 5\u2009years, and 50% were consensus\u2010based without systematic evidence synthesis. Most (90%) endorsed supportive measures such as wound care, nutritional support, and fluid resuscitation. Recommendations for pharmacologic therapy varied considerably: intravenous immunoglobulin (50%), systemic corticosteroids (40%), and cyclosporine (40%), with limited pediatric dosing guidance. Only one guideline mentioned biologics. Multidisciplinary care was recommended in 90%, yet long\u2010term follow\u2010up for sequelae appeared in only 50%. AGREE II appraisal showed high clarity of presentation but consistently low applicability; only the British Association of Dermatologists guideline achieved high quality across all domains. Current pediatric SJS\/TEN guidelines display heterogeneity in scope and rigor. While supportive care is emphasized, pharmacologic and long\u2010term management guidance remains inconsistent. Standardized, evidence\u2010based, pediatric\u2010specific guidelines are urgently needed.<\/jats:p>","DOI":"10.1111\/pde.70149","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T23:20:25Z","timestamp":1771284025000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosis and Management of Stevens\u2010Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Patients: A Systematic Review of Clinical Guidelines and Consensus Statements"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4679-9593","authenticated-orcid":false,"given":"Rachel","family":"Creighton","sequence":"first","affiliation":[{"name":"Faculty of Medicine Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Gupta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Langille","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Dermatology Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Dermatology Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17841"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16561"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2024.103282"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13725"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"52","article-title":"Clinical Features, Outcomes and Treatment in Children With Drug Induced Stevens\u2010Johnson Syndrome and Toxic Epidermal Necrolysis","volume":"90","author":"Liotti L.","year":"2019","journal-title":"Acta Bio Medica: Atenei Parmensis"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.191134"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15515"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15516"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3181a28c82"},{"key":"e_1_2_8_12_1","unstructured":"AGREE Next Steps Consortium: AGREE Research Trust \u201cAppraisal of Guidelines for Research & Evaluation II: AGREE II Instrument and User's Manual \u201dPublished online 2009 updated September 2013 https:\/\/www.agreetrust.org\/wp\u2010content\/uploads\/2013\/10\/AGREE\u2010II\u2010Users\u2010Manual\u2010and\u201023\u2010item\u2010Instrument_2009_UPDATE_2013.pdf."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2020634"},{"key":"e_1_2_8_14_1","unstructured":"Fimarad \u201cN\u00e9crolyse \u00e9pidermique chez l'enfant: Protocole national de diagnostic et de soins (PNDS). Fili\u00e8re Sant\u00e9 Maladies Rares Dermatologiques \u201dPublished online October 2021."},{"key":"e_1_2_8_15_1","volume-title":"Standard Treatment Guidelines 2022","author":"Indian Academy of Pediatrics","year":"2022"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.1.4.563"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.066"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622319894469"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burnso.2023.03.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00725-w"},{"key":"e_1_2_8_22_1","first-page":"51","article-title":"The Role of Systemic Corticosteroid Therapy in Erythema Multiforme Major and Stevens\u2010Johnson Syndrome: A Review of Past and Current Opinions","volume":"2","author":"Michaels B.","year":"2009","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.09.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.127249"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.4767"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15360"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1136"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00928-w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15676"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T18:19:24Z","timestamp":1779646764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pde.70149"],"URL":"https:\/\/doi.org\/10.1111\/pde.70149","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}