{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:24Z","timestamp":1785434784803,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Although skin diseases in Down syndrome (DS) have been investigated, nail disorders remain understudied. This study aims to evaluate the prevalence and clinical characteristics of nail disorders in children with DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multicenter, case\u2013control study in which 221 children with DS and 160 healthy children were recruited from 9 tertiary dermatology centers. A detailed nail and skin examination was performed by an experienced dermatologist in each center. Nail disorders were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 221 children with DS, 57% (126\/221) had at least one nail disorder. The prevalence of nail disorders in the DS group was significantly higher than in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). Brittle nail was the most common nail disorder (19.0%, 42\/221) in children with DS, followed by Beau's lines and onychomadesis (16.3%, 36\/221), longitudinal ridging (12.7%, 28\/221), and self\u2010induced nail disorders (onychophagia, habitual tic deformity, and onychotillomania) (10.0%, 22\/221). The risk of any nail disorder was 3 times higher, brittle nails 4.3 times, Beau's lines and onychomadesis 5.6 times, self\u2010induced nail disorders 1.6 times, and longitudinal ridging 3.4 times higher in DS compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nail disorders, including brittle nails, Beau's lines, and onychomadesis, self\u2010induced nail disorders, and longitudinal ridging, are common in DS. The identification of nail disorders in DS may aid in recognizing underlying systemic or psychiatric conditions, thereby supporting more comprehensive care for children with DS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.70160","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:59:46Z","timestamp":1773197986000},"page":"829-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nail Disorders in Children With Down Syndrome: A Multicenter Study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-8249","authenticated-orcid":false,"given":"Sezgi","family":"Sarikaya Solak","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Trakya University  Edirne T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-3892","authenticated-orcid":false,"given":"Filiz","family":"Cebeci Kahraman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kartal Dr. L\u00fctfi K\u0131rdar Training and Research Hospital University of Health Sciences  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-4551","authenticated-orcid":false,"given":"\u0130sa","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sanliurfa Training and Research Hospital  Sanliurfa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Kaya Erdogan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Eskisehir Osmangazi University  Eskisehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Emre","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-4652","authenticated-orcid":false,"given":"Rukiye","family":"Yasak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkin","family":"Zindanci","sequence":"additional","affiliation":[{"name":"Haydarpa\u015fa Numune Training and Research Hospital University of Health Sciences  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdi","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Uludag University  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Istanbul Medipol University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-7801","authenticated-orcid":false,"given":"Eda","family":"Oksum Solak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil","family":"Savas Erdogan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sultan 2, Abd\u00fclhamid Han Training and Research Hospital University of Health Sciences  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Kontbay Cetin","sequence":"additional","affiliation":[{"name":"Sanliurfa Training and Research Hospital, Clinic of Pediatric Endocrinology  Sanliurfa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-1873","authenticated-orcid":false,"given":"Kursad Bora","family":"Carman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Faculty of Medicine Eski\u015fehir Osmangazi University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Boyraz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine Ankara Yildirim Beyazit University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine Cumhuriyet University  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