{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:04:11Z","timestamp":1785434651019,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The rubella virus vaccine strain can cause granulomas in patients with inborn errors of immunity that may evolve into chronic, recalcitrant ulcers. This report details treatment of ulcerated rubella granulomas in a patient with ataxia telangiectasia with doxycycline and hydroxychloroquine resulting in partial ulcer healing within 4\u2009weeks, which in turn enabled surgical excision. Though this treatment did not cure or clear the rubella virus, that is known to persist in patients with inborn errors of immunity like ataxia telangiectasia, it enabled durable local lesion control of typically chronic, highly morbid ulcers. Histopathology of skin and bone lesions, the latter not previously described in the literature, is included.<\/jats:p>","DOI":"10.1111\/pde.70174","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:30:46Z","timestamp":1773106246000},"page":"929-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapy With Doxycycline and Hydroxychloroquine Enables Surgical Excision of Ulcerated Cutaneous Granulomas in a Patient With Ataxia Telangiectasia"],"prefix":"10.1111","volume":"43","author":[{"given":"Luis","family":"Murgu\u00eda\u2010Favela","sequence":"first","affiliation":[{"name":"Section of Hematology and Immunology, Department of Pediatrics Alberta Children's Hospital and University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Maruschak\u2010Love","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertson A.","family":"Harrop","sequence":"additional","affiliation":[{"name":"Section of Plastic Surgery, Department of Surgery Alberta Children's Hospital and University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Anne","family":"Brundler","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory University of Calgary; Pediatric Pathology, Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Kurek","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah; Pediatric Pathology, Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Public Health Laboratory, Alberta Precision Laboratories, Calgary, AB, Canada &amp; Department of Microbiology, Immunology &amp; Infectious Diseases University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-3611","authenticated-orcid":false,"given":"Michele L.","family":"Ramien","sequence":"additional","affiliation":[{"name":"Section of Community Pediatrics, Department of Pediatrics Alberta Children's Hospital and University of Calgary  Calgary Alberta Canada"},{"name":"Division of Dermatology, Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12616"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.05.058"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010018\u20100581\u20100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12411"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010019\u20100589\u20100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796065"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366840"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15568"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415626085"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419825780"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22157"},{"key":"e_1_2_8_15_1","first-page":"1660","volume-title":"Dermatology 5th Edition","author":"Rosenbach M. 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