{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:45Z","timestamp":1789571145632,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epidermolysis bullosa simplex\u2010severe (EBS\u2010severe) caused by\n                    <jats:italic>KRT5<\/jats:italic>\n                    p.Glu477Lys is a rare and particularly severe subtype associated with high neonatal morbidity and mortality. We report an infant who during the neonatal period required prolonged multidisciplinary intensive care for the management of several complications, including extensive wounds with blood loss leading to secondary anemia, failure to thrive with gastroesophageal reflux, respiratory distress with stridor and a necrotizing soft tissue infection, ultimately requiring surgical debridement and grafting. Pain control proved inadequate despite continuous morphine infusion, leading to initiation of methadone, which provided effective and stable analgesia. This case underscores the severe multisystem morbidity of\n                    <jats:italic>KRT5<\/jats:italic>\n                    p.Glu477Lys\u2013associated GS\u2010EBS and underscores the role of methadone in effective pain management in critically affected EB neonates.\n                  <\/jats:p>","DOI":"10.1111\/pde.70182","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:58:35Z","timestamp":1788537515000},"page":"46-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidermolysis Bullosa Simplex\u2010Severe Caused by\n                    <scp>\n                      <i>KRT5<\/i>\n                    <\/scp>\n                    p.\n                    <scp>Glu477Lys<\/scp>\n                    : Challenges Encountered in This High\u2010Risk Subtype"],"prefix":"10.1111","volume":"43","author":[{"given":"Nataliia","family":"Zhovta","sequence":"first","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Lanz","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Clinic for Dermatology and Allergology, Kantonsspital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Hafner","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Division of Plastic and Reconstructive Surgery, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Willi","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Division of Plastic and Reconstructive Surgery, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Eric","family":"Baller","sequence":"additional","affiliation":[{"name":"Neonatology Department University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Adzikah","sequence":"additional","affiliation":[{"name":"Neonatology Department University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Theiler","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Weibel","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Luchsinger","sequence":"additional","affiliation":[{"name":"Dermatology Department, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-1779","authenticated-orcid":false,"given":"Kathrin","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Division of Plastic and Reconstructive Surgery, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"K\u00fcpper","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Pediatric Skin Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Relly","sequence":"additional","affiliation":[{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Division of Infectious Diseases and Hospital Epidemiology University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Thomas","sequence":"additional","affiliation":[{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Anesthesia Department University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bergstr\u00e4sser","sequence":"additional","affiliation":[{"name":"Children's Research Center (CRC), University Children's Hospital Zurich University of Zurich  Zurich 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of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology Medical Center University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.024"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.039"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14105"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01896-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92759-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0210-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.01.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01472-z"}],"container-title":["Pediatric 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