{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:38:24Z","timestamp":1792636704440,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    NEMO\u2010deleted exon 5 autoinflammatory syndrome (NEMO\u2010NDAS) is the result of a gain\u2010of\u2010function\n                    <jats:italic>IKBKG<\/jats:italic>\n                    pathogenic variant leading to dysregulated NF\u2010\u03baB signaling and systemic inflammation. We present a case of NEMO\u2010NDAS in a 2\u2010year\u2010old female presenting with recurrent fevers, subcutaneous nodules, lymphadenopathy, and splenomegaly. This article highlights the symptoms that aid in diagnosis and how to differentiate it from other autoinflammatory diseases and reviews therapies for NEMO\u2010NDAS.\n                  <\/jats:p>","DOI":"10.1111\/pde.70199","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:20:12Z","timestamp":1773274812000},"page":"933-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>NEMO<\/scp>\n                    \u2010\n                    <scp>NDAS<\/scp>\n                    : Case Report and Review of the Literature"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6744-3035","authenticated-orcid":false,"given":"Angela","family":"Yang","sequence":"first","affiliation":[{"name":"Faculty of Science University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-8633","authenticated-orcid":false,"given":"Kristie","family":"Mar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Meesters","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3369","authenticated-orcid":false,"given":"Joseph M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","article-title":"A Systemic Autoinflammatory Syndrome Caused by NEMO Exon 5 Skipping","volume":"74","author":"Lin B.","year":"2022","journal-title":"Arthritis and Rheumatology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129301"},{"key":"e_1_2_8_4_1","first-page":"A214","article-title":"5PSQ\u2010108 Efficacy and Safety of Infliximab in NF\u2010KB Essential Modulator Deleted Exon 5 Auto\u2010Inflammatory Syndrome: A Case Report","volume":"31","author":"Bersali J.","year":"2024","journal-title":"British Medical Journal Publishing Group"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-024-00529-z"},{"issue":"9","key":"e_1_2_8_6_1","first-page":"1773","article-title":"Divergent Genetic Architecture in Boys and Girls With NEMO\u2010Deleted Exon 5 Autoinflammatory Syndrome (NEMO\u2010NDAS) Implies Role for Wildtype Effector Cells","volume":"76","author":"Almeida Jesus A.","year":"2024","journal-title":"Arthritis and Rheumatology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","unstructured":"A.Vergara I.Monge B.Fernandez Garoz et\u00a0al. \u201cDiagnostic Utility of Optical Genome Mapping in X\u2010Linked Dominant Genodermatoses: Incontinentia Pigmenti and CHILD Syndrome \u201dMolecular Syndromology 2025.","DOI":"10.1159\/000550167"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002144"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.10.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-13-S1-P154"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612594113"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi6794"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231941"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1371564"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00927"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-019-0322-9"},{"key":"e_1_2_8_17_1","unstructured":"J.Hill A.Marquez andM.Cossey \u201cPediatric Patient With Recurrent Fevers and Infections. Presented at Texas Pediatric Society Electronic Poster Contest (E\u2010Poster) \u201d 2022."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128808"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:00:00Z","timestamp":1792634400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/pde.70199"],"URL":"https:\/\/doi.org\/10.1111\/pde.70199","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"2025-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}