{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:55:59Z","timestamp":1790571359606,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    FIP1\u2010like\u20101\u2013platelet\u2010derived growth factor receptor\u2010\u03b1 (\n                    <jats:italic>FIP1L1\u2013PDGFRA<\/jats:italic>\n                    )\u2010positive hypereosinophilic syndrome (HES) is a rare myeloproliferative neoplasm characterized by persistent eosinophilia and occurs predominantly in middle\u2010aged adults. We report a 15\u2010year\u2010old boy with\n                    <jats:italic>FIP1L1\u2013PDGFRA<\/jats:italic>\n                    \u2010associated chronic eosinophilic leukemia who initially presented with persistent hemorrhagic crusts on the lower lip, an uncommon mucocutaneous manifestation resulting from thrombotic aggregates of eosinophil granule proteins. This case is followed by a systematic literature review of pediatric\n                    <jats:italic>FIP1L1\u2013PDGFRA<\/jats:italic>\n                    \u2010positive HES to further characterize its clinical features and outcomes in children.\n                  <\/jats:p>","DOI":"10.1111\/pde.70233","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:05:07Z","timestamp":1776827107000},"page":"1204-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Hemorrhagic Lip Crusts as the Presenting Sign of Pediatric\n                    <i>FIP1L1<\/i>\n                    \u2013\n                    <i>PDGFRA<\/i>\n                    \u2010Positive Hypereosinophilic Syndrome: A Case Report and Review of the Literature"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8609","authenticated-orcid":false,"given":"Yi\u2010Kuan","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-8753","authenticated-orcid":false,"given":"Yi\u2010Hsin","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University  Taipei 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