{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:56:03Z","timestamp":1790571363306,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X\u2010linked dominant disorder that primarily affects the skin and skeletal system but can also involve multiple organ systems. The disease usually presents with unilateral dermatological and skeletal abnormalities; however, rarely might bilateral involvement occur. This condition is associated with mutations in the\n                    <jats:italic>NSDHL<\/jats:italic>\n                    gene, which affects cholesterol biosynthesis. Herein, we report a 7\u2010year\u2010old female with bilateral involvement and a novel c.449\u2009T&gt;C (p.Phe150Ser) mutation in the\n                    <jats:italic>NSDHL<\/jats:italic>\n                    gene whose lesions cleared completely with topical cholesterol\u2013lovastatin cream.\n                  <\/jats:p>","DOI":"10.1111\/pde.70247","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:02:06Z","timestamp":1777964526000},"page":"1220-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Involvement in\n                    <scp>CHILD<\/scp>\n                    Syndrome Successfully Treated With Cholesterol\u2013Lovastatin Combination"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1943-1771","authenticated-orcid":false,"given":"Metin","family":"Zeyrek","sequence":"first","affiliation":[{"name":"Hacettepe University, School of Medicine Department of Dermatology and Venereology  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3438-8844","authenticated-orcid":false,"given":"Kerem","family":"Balan","sequence":"additional","affiliation":[{"name":"Hacettepe University, School of Medicine Department of Dermatology and Venereology  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-2476","authenticated-orcid":false,"given":"Sibel","family":"Ersoy\u2010Evans","sequence":"additional","affiliation":[{"name":"Hacettepe University, School of Medicine Department of Dermatology and Venereology  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"StatPearls [Internet]","author":"Ramphul K.","year":"2024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1293_20"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.113680"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20198789"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15838"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480\u2010200312000\u201000011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(97)70031\u20108"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13636"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(90)70285\u2010p"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14865"},{"key":"e_1_2_7_12_1","volume-title":"GeneReviews((R))","author":"Kurban M.","year":"1993"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:25:12Z","timestamp":1790569512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/pde.70247"],"URL":"https:\/\/doi.org\/10.1111\/pde.70247","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}