{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:53:02Z","timestamp":1781484782906,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Erythroderma in the pediatric population is an uncommon yet challenging condition. The etiologies encompass a wide variety of illnesses, including seborrheic dermatitis, infections, inborn errors of immunity, ichthyosiform disorders and metabolic abnormalities. Hyper\u2010immunoglobulin E syndrome (HIES) occurs due to various known genetic variants, e.g.,\n                    <jats:italic>STAT3<\/jats:italic>\n                    (signal transducer and activator of transcription\u20103),\n                    <jats:italic>IL6R<\/jats:italic>\n                    (Interleukin\u20106 receptor) deficiency and others, with an extensive list of features including erythroderma in childhood. Our case describes association of a possible novel mutation in\n                    <jats:italic>IFIH1<\/jats:italic>\n                    (interferon\u2010induced with helicase C domain 1) gene with HIES, which may aid in deciphering the complex nature of this disorder.\n                  <\/jats:p>","DOI":"10.1111\/pde.70274","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:13:41Z","timestamp":1781482421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel\n                    <scp>\n                      <i>IFIH1<\/i>\n                    <\/scp>\n                    Mutation Causing Hyper\u2010\n                    <scp>IgE<\/scp>\n                    Syndrome Presenting as Childhood Erythroderma: Case Report"],"prefix":"10.1111","author":[{"given":"Vasudha","family":"Belgaumkar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy Byramjee Jeejeebhoy Government Medical College, Sassoon General Hospital  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2830-3886","authenticated-orcid":false,"given":"Sukhdeep","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy Byramjee Jeejeebhoy Government Medical College, Sassoon General Hospital  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Tolat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy Byramjee Jeejeebhoy Government Medical College, Sassoon General Hospital  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy Byramjee Jeejeebhoy Government Medical College, Sassoon General Hospital  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"177","volume-title":"Dermatology","author":"Whittaker S.","year":"2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2024.07.028"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/0378-6323.66576","article-title":"Erythroderma in Children","volume":"76","author":"Sarkar R.","year":"2010","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-4632.2006.02849.x","article-title":"Erythroderma\/Generalized Exfoliative Dermatitis in Pediatric Practice: An Overview","volume":"45","author":"Sehgal V. N.","year":"2006","journal-title":"International Journal of Dermatology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1346-8138.1999.tb02036.x","article-title":"Erythroderma in Children: A Clinico\u2010Etiological Study","volume":"26","author":"Sarkar R.","year":"1999","journal-title":"Journal of Dermatology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/adc.79.2.186","article-title":"Neonatal Erythroderma: Differential Diagnosis and Management of the \u201cRed Baby\u201d","volume":"79","author":"Hoeger P. H.","year":"1998","journal-title":"Archives of Disease in Childhood"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/archderm.136.7.875","article-title":"Neonatal and Infantile Erythroderma: A Retrospective Study of 51 Patients","volume":"136","author":"Pruszkowski A.","year":"2000","journal-title":"Archives of Dermatology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(66)90119\u2010X"},{"issue":"1","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","article-title":"Extreme Hyperimmunoglobulinemia E and Undue Susceptibility to Infection","volume":"49","author":"Buckley R. H.","year":"1972","journal-title":"Pediatrics"},{"issue":"16","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 Mutations in the Hyper\u2010IgE Syndrome","volume":"357","author":"Holland S. M.","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMra1202117","article-title":"JAKs and STATs in Immunity, Immunodeficiency, and Cancer","volume":"368","author":"O'Shea J. J.","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70497"},{"issue":"4","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/humu.23975","article-title":"Genetic and Phenotypic Spectrum Associated With IFIH1 Gain\u2010Of\u2010Function","volume":"41","author":"Rice G. I.","year":"2020","journal-title":"Human Mutation"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/imcb.12209","article-title":"Hyper IgE Syndromes: Clinical and Molecular Characteristics","volume":"97","author":"Al\u2010Shaikhly T.","year":"2019","journal-title":"Immunology and Cell Biology"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"133","article-title":"Ichthyosis Linearis Circumflexa","volume":"98","author":"Comel M.","year":"1949","journal-title":"Dermatologica"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1001\/archdermatol.2008.510","article-title":"Eczematous Dermatitis in the Setting of Hyper\u2010IgE Syndrome Successfully Treated With Omalizumab","volume":"144","author":"Bard S.","year":"2008","journal-title":"Archives of Dermatology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"835257","DOI":"10.3389\/fmed.2022.835257","article-title":"Omalizumab for STAT3 Hyper\u2010IgE Syndromes in Adulthood: A Case Report and Literature Review","volume":"9","author":"Lan J.","year":"2022","journal-title":"Frontiers in Medicine"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10875-014-0126-0","article-title":"DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options \u2010 a Review of 136 Patients","volume":"35","author":"Aydin S. 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