{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:13:41Z","timestamp":1784632421889,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Progressive hemifacial atrophy (PHA) or Parry\u2010Romberg syndrome is a rare, insidiously progressive disorder that typically presents in childhood and is considered part of the morphea spectrum. This longitudinal, ambispective, observational study included 8 pediatric patients (4 female) diagnosed with PHA, with a mean age at symptom onset of 4.5\u2009\u00b1\u20092\u2009years and at diagnosis of 8.2\u2009\u00b1\u20092.9\u2009years. All 8 patients presented superficial and deep cutaneous findings (dyspigmentation, dermal and subcutaneous atrophy, and facial asymmetry); 7 had associated extracutaneous abnormalities (maxillofacial, ophthalmological, and neurological), all received systemic immunosuppressive therapy (average of 2.2\u2009\u00b1\u20091 regimens for a mean duration of 35.2\u2009\u00b1\u200929.3\u2009months), and 4 had subsequent fat grafting procedures. In conclusion, pediatric patients with PHA suffer an important diagnostic delay, require long\u2010term treatment with multiple immunosuppressive drugs and surgical interventions, as well as multidisciplinary management of frequent associated extracutaneous abnormalities.<\/jats:p>","DOI":"10.1111\/pde.70321","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:53:51Z","timestamp":1784631231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Patients With Progressive Hemifacial Atrophy: Clinical Features, Course, and Treatment"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-6495","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Z\u00fa\u00f1iga\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Dermatology Department Instituto Nacional de Pediatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8191-0178","authenticated-orcid":false,"given":"Mariana Alexandra","family":"Rivera\u2010Salazar","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Nacional de Pediatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Scheffler\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Inmunology Instituto Nacional de Pediatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-8109","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Garc\u00eda\u2010Romero","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Nacional de Pediatr\u00eda  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"S. S.ShahandM.Chhabra \u201cParry\u2010Romberg Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan \u201dPublished 2022 Nov 8."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051219"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000785"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010214697"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010015\u20100250\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.959"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12969-021-00512-6","article-title":"Magnetic Resonance Imaging Findings in Children With Parry\u2010Romberg Syndrome and en Coup de Sabre","volume":"19","author":"Knights H.","year":"2021","journal-title":"Pediatric Rheumatology Online Journal"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"358","article-title":"Parry\u2010Romberg, un S\u00edndrome Neurocut\u00e1neo: Presentaci\u00f3n de Tres Casos","volume":"58","author":"Acevedo A.","year":"2020","journal-title":"Revista M\u00e9dica Del Instituto Mexicano Del Seguro Social"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijscr.2021.01.006","article-title":"Lipofilling as an Aesthetic Restorative Technique for the Facial Hemiatrophy of Parry\u2010Romberg Syndrome: An Analysis of 27 Cases","volume":"79","author":"Aloua R.","year":"2021","journal-title":"International Journal of Surgery Case Reports"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:53:53Z","timestamp":1784631233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":10,"alternative-id":["10.1111\/pde.70321"],"URL":"https:\/\/doi.org\/10.1111\/pde.70321","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70321"}}