{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:59:21Z","timestamp":1785110361864,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Warts are a common pediatric condition caused by human papillomavirus. Immunotherapy is a well\u2010studied treatment for warts and is classically administered via intralesional injection with a syringe and needle. We report a case of warts in a 12\u2010year\u2010old boy who achieved complete resolution following two sessions of pain\u2010free, and needleless, intralesional Candida antigen administered using a needle free jet injection device. This is a less painful alternative for administration of intralesional immunotherapy, particularly useful in pediatric or needle phobic patients.<\/jats:p>","DOI":"10.1111\/pde.70323","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:25:38Z","timestamp":1785108338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Jet Injections With Candida Antigen for Wart Treatment: An Alternative Drug Delivery"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3733-1136","authenticated-orcid":false,"given":"Mary Nan","family":"Leath","sequence":"first","affiliation":[{"name":"College of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5896-5357","authenticated-orcid":false,"given":"Theodore","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Missouri\u2010Columbia  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-3062","authenticated-orcid":false,"given":"Kimberly","family":"Eisenstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Missouri\u2010Columbia  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1394","volume-title":"Dermatology","author":"Kirnbauer R.","year":"2025"},{"issue":"4","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/2230-973X.167662","article-title":"Needle Free Injection Technology: A Complete Insight","volume":"5","author":"Ravi A.","year":"2015","journal-title":"International Journal of Pharmaceutical Investigation"},{"issue":"2","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1213\/01.ane.0000194293.10549.62","article-title":"A Comparison of a Needle\u2010Free Injection System for Local Anesthesia Versus EMLA for Intravenous Catheter Insertion in the Pediatric Patient","volume":"102","author":"Jimenez N.","year":"2006","journal-title":"Anesthesia and Analgesia"},{"issue":"5","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.annemergmed.2015.04.003","article-title":"A Randomized Clinical Trial of Jet\u2010Injected Lidocaine to Reduce Venipuncture Pain for Young Children","volume":"66","author":"Lunoe M. M.","year":"2015","journal-title":"Annals of Emergency Medicine"},{"issue":"2","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/09546630600621987","article-title":"Dermojet Delivery of Bleomycin for the Treatment of Recalcitrant Plantar Warts","volume":"17","author":"Agius E.","year":"2006","journal-title":"Journal of Dermatological Treatment"},{"issue":"3","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1524-4725.1995.tb00155.x","article-title":"The Treatment of Palmar and Plantar Warts Using Natural Alpha Interferon and a Needleless Injector","volume":"21","author":"Brodell R. T.","year":"1995","journal-title":"Dermatologic Surgery"},{"issue":"3","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2003.10.356","article-title":"A New and Effective Delivery System of Bleomycin for the Treatment of Recalcitrant Warts","volume":"50","author":"Jones J. M.","year":"2004","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"6","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/pde.12667","article-title":"Intralesional Candida Antigen Immunotherapy for the Treatment of Recalcitrant and Multiple Warts in Children","volume":"32","author":"Mu\u00f1oz Garza F. Z.","year":"2015","journal-title":"Pediatric Dermatology"},{"issue":"3","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jdcr.2018.01.010","article-title":"An Aberrant Reaction to \n                     Candida albicans\n                   Antigen Used for Recalcitrant Warts Successfully Treated With Oral Prednisone","volume":"4","author":"La'Pelusa A.","year":"2018","journal-title":"JAAD Case Reports"},{"issue":"4","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1525-1470.2008.00723.x","article-title":"Central Retinal Artery Occlusion Following Forehead Injection With a Corticosteroid Suspension","volume":"25","author":"Edwards A. O.","year":"2008","journal-title":"Pediatric Dermatology"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:25:46Z","timestamp":1785108346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":10,"alternative-id":["10.1111\/pde.70323"],"URL":"https:\/\/doi.org\/10.1111\/pde.70323","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"2026-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70323"}}