{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:25:44Z","timestamp":1787970344305,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The neonatal period represents a critical window for skin barrier maturation, microbial colonization, and immune development. As such, early\u2010life exposures may exert lasting effects on dermatologic and systemic health. A common early\u2010life exposure is blue light phototherapy (BLP), a life\u2010saving treatment for neonatal hyperbilirubinemia. Although BLP is traditionally regarded as a localized, superficial intervention, emerging evidence suggests that it is a biologically active exposure that directly interacts with developing skin, thereby influencing barrier integrity, the developing microbiome, and immune signaling. As an active immune organ, neonatal skin has been proposed to engage in dynamic crosstalk with the nervous, gut, and endocrine systems. Therefore, BLP may act systemically by modulating these interconnections. These effects raise concerns about the potential long\u2010term impact of BLP during this critical developmental period. The development of immune\u2010mediated conditions, such as atopic dermatitis (AD), is of particular interest as they are hypothesized to engage in these cross\u2010system networks. This review examines the multifactorial relationship between BLP and neonatal skin development, highlighting BLP as an active exposure that may interact with developing skin, microbiome, and immune system, while emphasizing the need for longitudinal studies to clarify long\u2010term clinical implications.<\/jats:p>","DOI":"10.1111\/pde.70330","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:14:16Z","timestamp":1787969656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Illuminating Connections: Exploring the Dynamic Relationship Between Phototherapy and the Skin"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7772-2026","authenticated-orcid":false,"given":"Meshi","family":"Paz","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-0152","authenticated-orcid":false,"given":"Peter","family":"Lio","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Medical Dermatology Associates of Chicago  Chicago Illinois 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\u201cPostbiotics and Atopic Dermatitis: Aiming to Modulate the Gut\u2010Skin Axis \u201dJournal of Integrated Dermatology [Internet] 2024 cited August 18 2024 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