{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:54:29Z","timestamp":1786121669879,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This is the case of a 10\u2010year\u2010old female with\n                    <jats:italic>HRAS<\/jats:italic>\n                    \u2010related epidermal nevus syndrome with extensive and severe cutaneous involvement treated with oral sirolimus. The patient had progressively enlarging verrucous periorbital plaques involving the eyelids, resulting in lagophthalmos and threatening vision. Oral sirolimus rapidly improved the cutaneous lesions and resolved the lagophthalmos. This case of a patient treated with oral sirolimus for HRAS\u2010related epidermal nevus syndrome suggests that therapies targeting the mTOR pathway may indirectly affect the RAS\/MAPK pathway.\n                  <\/jats:p>","DOI":"10.1111\/pde.70339","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:53:28Z","timestamp":1786082008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Sirolimus Treatment for\n                    <scp>HRAS<\/scp>\n                    \u2010Related Epidermal Nevus Syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6221-2714","authenticated-orcid":false,"given":"Moira","family":"Shea","sequence":"first","affiliation":[{"name":"Department of Dermatology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9419-4704","authenticated-orcid":false,"given":"Milie M.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3951-8580","authenticated-orcid":false,"given":"Liza","family":"Kenny","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda D.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u2013 Division of Hematology and Oncology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-1448","authenticated-orcid":false,"given":"Tracy","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Department of Pediatrics Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.05.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14323"},{"key":"e_1_2_8_4_1","volume-title":"StatPearls [Internet]","author":"Nicholson C. 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