{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:53:15Z","timestamp":1791438795827,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Loose anagen hair syndrome (LAHS) is a rare, non\u2010scarring alopecia that may occur sporadically or follow autosomal dominant inheritance. The objective of this study was to review the etiology, clinical presentation, diagnostic features (including trichoscopy, trichogram, and microscopy), natural history, and treatment outcomes of LAHS. A scoping review was conducted using MEDLINE, Embase, Web of Science, Scopus, and CENTRAL databases. Seventy\u2010six studies, encompassing 425 patients with LAHS (mean age: 6.2\u2009years), were included. Most patients were female (78.6%) with Type A LAHS (88.5%). The most common trichoscopic findings were follicular units containing single hairs (92.9%) and rectangular black granular structures (57.5%). Genetic associations included mutations in keratin genes (e.g.,\n                    <jats:italic>KRT32<\/jats:italic>\n                    ,\n                    <jats:italic>KRT71<\/jats:italic>\n                    , and related keratin family genes) and syndromic overlap, most prominently Noonan\u2010like syndrome with loose anagen hair. 16.8% received treatment, primarily with topical minoxidil (88.2%). Complete resolution occurred in 14.7% of treated patients and two untreated patients. Evidence was limited predominantly to case reports and case series, with inconsistent follow\u2010up data. LAHS should be considered in children presenting with diffuse shedding and easily extractable hair. Topical or oral minoxidil may be beneficial, but further studies are needed to clarify the natural history and comparative effectiveness of treatment.\n                  <\/jats:p>","DOI":"10.1111\/pde.70342","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:14:32Z","timestamp":1791436472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loose Anagen Hair Syndrome: A Scoping Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8180-7427","authenticated-orcid":false,"given":"Romy","family":"Shenderey","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2370-0247","authenticated-orcid":false,"given":"Hailey","family":"Land","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-7999","authenticated-orcid":false,"given":"Eric","family":"McMullen","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9662-1508","authenticated-orcid":false,"given":"Daniela","family":"Giansante","sequence":"additional","affiliation":[{"name":"Department of Psychology, Neuroscience, and Behaviour McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Xiong","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-7501","authenticated-orcid":false,"given":"Katya","family":"Peri","sequence":"additional","affiliation":[{"name":"McGill University Faculty of Medicine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Ocvirk","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Trasolini","sequence":"additional","affiliation":[{"name":"Department of Biochemistry McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-5102","authenticated-orcid":false,"given":"Laurence","family":"Mainville","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Toronto  Toronto Ontario Canada"},{"name":"Division of Dermatology, Department of Medicine, CHU de Qu\u00e9bec Universit\u00e9 Laval  Qu\u00e9bec City Quebec Canada"},{"name":"Division of Dermatology, Department of Medicine Women's College Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1658-4947","authenticated-orcid":false,"given":"Shireen","family":"Dumont","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Women's College Hospital  Toronto Ontario Canada"},{"name":"Department of Dermatology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-1170","authenticated-orcid":false,"given":"Narachai","family":"Julanon","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1121","authenticated-orcid":false,"given":"Cathryn","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Toronto  Toronto Ontario Canada"},{"name":"Division of Dermatology, Department of Pediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8623-2974","authenticated-orcid":false,"given":"Jeffrey","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia Canada"},{"name":"Donovan Hair Clinic  Whistler British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-22-00125"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.01.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00572.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506524"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61363"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61638"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_147_22"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501443"},{"issue":"2","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.5070\/D3272052386","article-title":"Loose Anagen Syndrome in One Identical Twin Girl","volume":"27","author":"Flanigan K.","year":"2021","journal-title":"Dermatology Online Journal"},{"issue":"4","key":"e_1_2_9_12_1","article-title":"Heterozygous KRT32 Variant Is Responsible for Autosomal Dominant Loose Anagen Hair Syndrome","volume":"6","author":"Melo M.","year":"2025","journal-title":"HGG Advances"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes16040459"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19481"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-24-113"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62733"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.04.009"},{"issue":"1","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10048-025-00832-9","article-title":"Complete Commissural Agenesis in a Child With Noonan\u2010Like Syndrome With Loose Anagen Hair 2","volume":"26","author":"Gana S.","year":"2025","journal-title":"Neurogenetics"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-023-00939-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15643"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.07.033"},{"issue":"2","key":"e_1_2_9_22_1","first-page":"332","article-title":"Uncombable Hair Syndrome With Loose Anagen Syndrome: A Rare Association","volume":"21","author":"Agrawal D.","year":"2020","journal-title":"Indian Journal of Paediatric Dermatology"},{"issue":"2","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/ijt.ijt_100_18","article-title":"Loose Anagen Syndrome: A Little Response to Minoxidil","volume":"11","author":"Anouar I.","year":"2019","journal-title":"International Journal of 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P.","year":"1992","journal-title":"Archives of Dermatology"},{"issue":"4","key":"e_1_2_9_29_1","first-page":"272","article-title":"Loose Anagen Hair Syndrome in a Dark Hair Patient: First Case Report in Mexico","volume":"9","author":"Fuente Garc\u00eda A.","year":"2011","journal-title":"Dermatolog\u00eda Cosm\u00e9tica, M\u00e9dica y Quir\u00fargica"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.77513"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:14:34Z","timestamp":1791436474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":30,"alternative-id":["10.1111\/pde.70342"],"URL":"https:\/\/doi.org\/10.1111\/pde.70342","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70342"}}