{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:50:51Z","timestamp":1791438651699,"version":"4.3.3"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dupilumab has emerged as a promising treatment for inflammatory dermatitis in some epidermal differentiation disorders (EDDs, formerly known as ichthyosis). We report a 5\u2010month\u2010old female with recurrent generalized skin peeling and erythematous plaques since birth that were refractory to multiple topical therapies; she was diagnosed with\n                    <jats:italic>ALOXE3<\/jats:italic>\n                    \u2010associated nonsyndromic epidermal differentiation disorder (\n                    <jats:italic>ALOXE3<\/jats:italic>\n                    \u2010nEDD) by whole exome sequencing. Following initiation of dupilumab, she experienced near\u2010complete resolution of erythematous plaques within 9\u2009months and improvement of pruritus, with sustained response over 2\u2009years of treatment. This case highlights dupilumab as a potential treatment for inflammatory dermatitis associated with\n                    <jats:italic>ALOXE3<\/jats:italic>\n                    \u2010nEDD and similar EDDs.\n                  <\/jats:p>","DOI":"10.1111\/pde.70350","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:02:14Z","timestamp":1791435734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of Inflammatory Dermatitis Associated With\n                    <i>ALOXE3<\/i>\n                    Nonsyndromic Epidermal Differentiation Disorder Using Dupilumab"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-9870","authenticated-orcid":false,"given":"Hsing\u2010Jou","family":"Su","sequence":"first","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-7193","authenticated-orcid":false,"given":"Rosalynn M.","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Department of Pathology Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-3339","authenticated-orcid":false,"given":"Elena B.","family":"Hawryluk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.1.107"},{"key":"e_1_2_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf154"},{"key":"e_1_2_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12950"},{"key":"e_1_2_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.027"},{"key":"e_1_2_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae420"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:02:15Z","timestamp":1791435735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":5,"alternative-id":["10.1111\/pde.70350"],"URL":"https:\/\/doi.org\/10.1111\/pde.70350","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70350"}}