{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:06:08Z","timestamp":1789135568820,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare skin disorder characterized by pruritic, erythematous, and scaly plaques following Blaschko's lines. Known genetic causes include somatic variants in\n                    <jats:italic>CARD14<\/jats:italic>\n                    and\n                    <jats:italic>GJA1<\/jats:italic>\n                    . In addition, a similar phenotype of congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) nevus has been associated with germline pathogenic variants in\n                    <jats:italic>NSDHL<\/jats:italic>\n                    encoding a NAD(P)\u2010dependent steroid dehydrogenase\u2010like protein essential for cholesterol biosynthesis. Here we report a case of ILVEN caused by a previously unreported germline pathogenic variant in\n                    <jats:italic>NSDHL<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pde.70355","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:08:53Z","timestamp":1789132133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Germline Missense Variant in the\n                    <i>NSDHL<\/i>\n                    Gene Underlies Inflammatory Linear Verrucous Epidermal Nevus"],"prefix":"10.1111","author":[{"given":"Janan","family":"Mohamad","sequence":"first","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4171-6668","authenticated-orcid":false,"given":"Kiril","family":"Malovitski","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; 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