{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:53:37Z","timestamp":1791359617173,"version":"4.3.1"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"ABSTRACT<\/jats:title>\n \n Urticarial eruptions in neonates, especially within hours to days of birth, should prompt workup for cryopyrin\u2010associated periodic syndrome (CAPS) disorders. This report details a 9\u2010h\u2010old neonate with urticaria as the first manifestation of neonatal onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurologic cutaneous and articular syndrome. Empiric anakinra was started on Day 3 of life, prior to genetic confirmation of a de novo pathogenic variant of\n NLRP3<\/jats:italic>\n , due to high clinical suspicion for CAPS and in the absence of an infectious source. As early treatment reduces morbidity and mortality, this case highlights the importance of having a low threshold for empiric anti\u2010IL\u20101 therapy in neonatal urticaria with clinical suspicion for NOMID.\n <\/jats:p>","DOI":"10.1111\/pde.70356","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:35:38Z","timestamp":1791358538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Urticaria as the First Manifestation of Neonatal Onset Multisystem Inflammatory Disease Treated Empirically With Anakinra"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2439-8321","authenticated-orcid":false,"given":"Adrienne","family":"Conza","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Massachusetts Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna M.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-5136","authenticated-orcid":false,"given":"Isabella","family":"Plumptre","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Chan Medical School Worcester Massachusetts USA"},{"name":"Department of Pediatrics University of Massachusetts Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-2862","authenticated-orcid":false,"given":"Mary Beth F.","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Belazarian","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Chan Medical School Worcester Massachusetts USA"},{"name":"Department of Pediatrics University of Massachusetts Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_1_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10688"},{"key":"e_1_2_1_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775140"},{"key":"e_1_2_1_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01812.x"},{"key":"e_1_2_1_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34409"},{"key":"e_1_2_1_8_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170041"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:35:39Z","timestamp":1791358539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":5,"alternative-id":["10.1111\/pde.70356"],"URL":"https:\/\/doi.org\/10.1111\/pde.70356","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pde.70356"}}