{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:03:33Z","timestamp":1791468213019,"version":"4.3.4"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A retrospective case series evaluated dupilumab as add\u2010on therapy in 15 children with severe alopecia areata who relapsed after achieving SALT80 with Janus kinase inhibitors. At Week 12, the median improvement in SALT score from baseline was 59.0%. Among the 13 patients who completed 24\u2009weeks of treatment, 84.6% achieved complete hair regrowth (SALT100). Dupilumab add\u2010on therapy demonstrated efficacy and acceptable safety, suggesting it may be a promising option for pediatric alopecia areata patients who relapse during JAK inhibitor treatment.<\/jats:p>","DOI":"10.1111\/pde.70379","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:33:02Z","timestamp":1791466382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab as Add\u2010On Therapy for\n                    <scp>JAK<\/scp>\n                    Inhibitor\u2010Relapsed Pediatric Alopecia Areata: A Case Series"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9862-3925","authenticated-orcid":false,"given":"Shengke","family":"Fang","sequence":"first","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-6364","authenticated-orcid":false,"given":"Xuesong","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University  Jinan Shandong China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_1_6_2_1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s40257-024-00884-x","article-title":"Predictors and Management of Inadequate Response to JAK Inhibitors in Alopecia Areata","volume":"25","author":"Zhang X.","year":"2024","journal-title":"American Journal of Clinical Dermatology"},{"key":"e_1_2_1_6_3_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/jdv.15489","article-title":"JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta\u2010Analysis","volume":"33","author":"Phan K.","year":"2019","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"e_1_2_1_6_4_1","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1111\/jocd.15903","article-title":"Relative Efficacy of Janus Kinase Inhibitors and Dupilumab in Alopecia Areata","volume":"22","author":"Gupta A. 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