{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:16:18Z","timestamp":1790363778436,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We define clinical predictors of neurological outcome in neonates with hypoxic\u2013ischemic encephalopathy undergoing hypothermia therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one neonates who underwent selective head cooling between 2004 and 2010 and were followed neurologically for \u226524 months were investigated retrospectively. Patients were divided according to the neurological outcome at 2 years of age into group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 11), patients with normal neurological function, and group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 10), patients with neurological disabilities (<jats:italic>n<\/jats:italic> = 9) or those who died (<jats:italic>n<\/jats:italic> = 1). Predictors were determined by \u03c7<jats:sup>2<\/jats:sup> and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney <jats:italic><jats:styled-content style=\"fixed-case\">U<\/jats:styled-content><\/jats:italic>\u2010tests, <jats:sc>anova<\/jats:sc>, Spearman rank correlations and receiver\u2013operator curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> showed higher average blood lactate levels during the first day, particularly at 24\u2009h of life; lower day\u20103 cerebral blood flow resistance index; higher maximum dobutamine dose used; higher rate of thiamylal sodium used; more severe background electroencephalogram suppression during the first week (group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>: 11\/11 cases \u2264 grade 3; group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>: 7\/9 cases at grade 4\u20135) and higher rate of cerebral lesions on magnetic resonance imaging in the second week (group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>: 1\/11 case; group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>: 9\/10 cases) than group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. The most useful predictor of poor prognosis was cerebral parenchymal lesions on magnetic resonance imaging with 90%, 90% and 90% of sensitivity, specificity and accuracy, followed by week\u20101 background electroencephalogram \u2265 grade 4 with 70%, 100% and 85% and day\u20103 cerebral blood flow resistance index &lt; 0.46 with 71%, 88% and 80%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prediction of post\u2010cooling neurological outcome could be improved substantially by evaluating multiple factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12008","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T01:13:27Z","timestamp":1353287607000},"page":"169-176","source":"Crossref","is-referenced-by-count":22,"title":["Predictors of neurological outcome in cooled neonates"],"prefix":"10.1111","volume":"55","author":[{"given":"Jingang","family":"Li","sequence":"first","affiliation":[{"name":"Department of 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