{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:18:29Z","timestamp":1765887509932},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) transplantation (BMT) is one of the treatment strategies for congenital metabolic disease, but leukemia secondary to intensive cytoreductive treatment is a major concern. Besides <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> cells, mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>) are also used for transplantation. An 8\u2010month\u2010old girl with hypophosphatasia underwent transplantation of haploidentical <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> cells followed by two transplants of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> obtained from her father to facilitate osteogenesis. <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ludarabine(<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>lu)\/cyclophosphamide (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>)\/anti\u2010thymocyte globulin were used for myeloablative conditioning, but the patient developed therapy\u2010related leukemia harboring t(9;22)(q34;q11.2); minor <jats:italic><jats:styled-content style=\"fixed-case\">BCR\u2010ABL<\/jats:styled-content><\/jats:italic> (t\u2010leukemia with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h) at the age of 32 months. At the age of 40 months she underwent a second <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> and third <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> transplant from the same donor. Thereafter, she achieved complete histological and molecular remission. The present case suggests that the combination of cytotoxic agents (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>lu\/<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> led to t\u2010leukemia with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>h as a consequence of chromosome instability and suppression of host anti\u2010tumor immunity.<\/jats:p>","DOI":"10.1111\/ped.12012","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T03:25:44Z","timestamp":1371612344000},"source":"Crossref","is-referenced-by-count":8,"title":["Therapy\u2010related <scp>P<\/scp>h+ leukemia after both bone marrow and mesenchymal stem cell transplantation for hypophosphatasia"],"prefix":"10.1111","volume":"55","author":[{"given":"Takeshi","family":"Taketani","sequence":"first","affiliation":[{"name":"Division of Blood Transfusion Shimane University Hospital  Shimane"},{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Mishima","sequence":"additional","affiliation":[{"name":"Division of Blood Transfusion Shimane University Hospital  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Research Institute for Cell Engineering National Institute of Advanced Industrial Science and Technology  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Katsube","sequence":"additional","affiliation":[{"name":"Research Institute for Cell Engineering National Institute of Advanced Industrial Science and Technology  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Yuba","sequence":"additional","affiliation":[{"name":"Research Institute for Cell Engineering National Institute of Advanced Industrial Science and Technology  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Ogushi","sequence":"additional","affiliation":[{"name":"Research Institute for Cell Engineering National Institute of Advanced Industrial Science and Technology  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Shimane"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPD85MCOHHCOMQ"},{"key":"e_1_2_5_3_1","first-page":"127","volume-title":"Therapy\u2010Related Myeloid Neoplasms. 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